Dr. Karl Deisseroth
๐ค SpeakerAppearances Over Time
Podcast Appearances
change the threshold for us to become aware of these incomplete hypotheses or wrong hypotheses or concepts that might be noise but are just wrong and so are never allowed to get into our conscious mind. Now, you know, that's pretty interesting and it goes wrong in psychiatric disorders.
change the threshold for us to become aware of these incomplete hypotheses or wrong hypotheses or concepts that might be noise but are just wrong and so are never allowed to get into our conscious mind. Now, you know, that's pretty interesting and it goes wrong in psychiatric disorders.
change the threshold for us to become aware of these incomplete hypotheses or wrong hypotheses or concepts that might be noise but are just wrong and so are never allowed to get into our conscious mind. Now, you know, that's pretty interesting and it goes wrong in psychiatric disorders.
I think in schizophrenia, sometimes the paranoid delusions that people have are examples of these poor models that escape into the conscious mind and become accepted as reality and they never should have gotten out there. Now, how could something like this, in the right way, help with something like depression? Patients with depression often are stuck.
I think in schizophrenia, sometimes the paranoid delusions that people have are examples of these poor models that escape into the conscious mind and become accepted as reality and they never should have gotten out there. Now, how could something like this, in the right way, help with something like depression? Patients with depression often are stuck.
I think in schizophrenia, sometimes the paranoid delusions that people have are examples of these poor models that escape into the conscious mind and become accepted as reality and they never should have gotten out there. Now, how could something like this, in the right way, help with something like depression? Patients with depression often are stuck.
They can't look into the future world of possibilities as effectively. Everything seems... hopeless. And what does that really mean? They discount the value of their own action. They discount the value of the world at giving rise to a future that matters. Everything seems to run out like a river just running out into a desert and drying up. And
They can't look into the future world of possibilities as effectively. Everything seems... hopeless. And what does that really mean? They discount the value of their own action. They discount the value of the world at giving rise to a future that matters. Everything seems to run out like a river just running out into a desert and drying up. And
They can't look into the future world of possibilities as effectively. Everything seems... hopeless. And what does that really mean? They discount the value of their own action. They discount the value of the world at giving rise to a future that matters. Everything seems to run out like a river just running out into a desert and drying up. And
And what these agents may do that increase the flow through circuitry, if you will, the percolation of activity through circuitry may end up doing for depression is increasing the escape of some tendrils of process, of forward progression through the world. That's a concept. It's how I think about it. There are ways we can make that rigorous. We can indeed identify in the brain by recording.
And what these agents may do that increase the flow through circuitry, if you will, the percolation of activity through circuitry may end up doing for depression is increasing the escape of some tendrils of process, of forward progression through the world. That's a concept. It's how I think about it. There are ways we can make that rigorous. We can indeed identify in the brain by recording.
And what these agents may do that increase the flow through circuitry, if you will, the percolation of activity through circuitry may end up doing for depression is increasing the escape of some tendrils of process, of forward progression through the world. That's a concept. It's how I think about it. There are ways we can make that rigorous. We can indeed identify in the brain by recording.
We can see cells that represent steps along a path and look into the future. And we can rigorously define these cells and we can see if these are altered on psychedelics. And so that's one of the reasons that we're working with these agents in the laboratory to say, is this really the case? Are these opening up new paths or representations of paths into the future?
We can see cells that represent steps along a path and look into the future. And we can rigorously define these cells and we can see if these are altered on psychedelics. And so that's one of the reasons that we're working with these agents in the laboratory to say, is this really the case? Are these opening up new paths or representations of paths into the future?
We can see cells that represent steps along a path and look into the future. And we can rigorously define these cells and we can see if these are altered on psychedelics. And so that's one of the reasons that we're working with these agents in the laboratory to say, is this really the case? Are these opening up new paths or representations of paths into the future?
I think the brain learns from those experiences. That's the way I see it. And so, for example, people who've taken MDMA, they will, as you say, they'll be the acute phase of being on the drug and experiencing this extreme connectedness with other people, for example. And then the drug wears off, but the brain learned from that experience.
I think the brain learns from those experiences. That's the way I see it. And so, for example, people who've taken MDMA, they will, as you say, they'll be the acute phase of being on the drug and experiencing this extreme connectedness with other people, for example. And then the drug wears off, but the brain learned from that experience.
I think the brain learns from those experiences. That's the way I see it. And so, for example, people who've taken MDMA, they will, as you say, they'll be the acute phase of being on the drug and experiencing this extreme connectedness with other people, for example. And then the drug wears off, but the brain learned from that experience.
And so what people will report is, yeah, I'm not in that state, but I saw what was possible. I saw, yeah, you can, There don't need to be barriers, or at least not as many barriers as I thought. I can connect with more people in a way that is helpful. And so I think it's the learning that happens in that state that actually matters.
And so what people will report is, yeah, I'm not in that state, but I saw what was possible. I saw, yeah, you can, There don't need to be barriers, or at least not as many barriers as I thought. I can connect with more people in a way that is helpful. And so I think it's the learning that happens in that state that actually matters.