Dr. Kyle Gillett

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556 appearances 2 recordings 1 series first heard Dec 2025 last heard 2 Jul

Dr. Kyle Gillett’s voice in public audio — every appearance, attributed to the second.

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Recordings per month over the last 12 months — 2 in all, peaking in Jul 2026 with 1.

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Huberman Lab · Essentials: Tools for Hormone Optimization in Males | Dr. Kyle Gillett · 2 Jul 2026 podcast

So one to four, maybe even five grams.

Correct.

Up to five grams a day.

If you're on that much, especially if you have a dysregulated gut microbiome, you should be concerned with TMAO, which is a potential carcinogen that both carnitine and choline can convert into.

Okay.

and your gut microbiota determine how much that happens.

There's a compound in garlic called allicin.

I believe it's A-L-L-I-C-I-N.

It's also part of the scientific name, the genus of types of garlic.

And this can help decrease the conversion to TMAO.

Berberine actually slightly decreases the conversion to TMAO as well, probably through alteration of the gut microbiome.

And then just optimizing your gut microbiome can decrease conversion.

So not everyone needs allicin, but it's something that you should certainly consider if you are on a high dose.

It has many other effects, including the dawn phenomenon where it drops your blood sugar when you're sleeping and you can't even realize it.

Okay.

And what we did not talk about is what L-carnitine does.

It's a shuttle.

So I think it's named carnitine palmitoyl coenzyme A. Basically, it just takes nutrients from outside your mitochondria and puts them in.

It also has a unique effect.

Well, not too unique because tadalafil actually has this effect as well, is that it increases the density of the androgen receptor in the cytoplasm of your cells.

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