Dr. Layne Norton

Now we can argue about particle size and all that kind of stuff.

But we know regardless of particle size, LDL can penetrate the endothelium and cause damage.

Okay, mechanism, right?

And then people say, well, inflammation.

Okay, well, if we look at the studies where they just –

have people eat more polyunsaturated fats.

Sometimes you see an increase in inflammation.

Sometimes you don't.

But if we look at the studies where they're substituting polyunsaturated fats in place of saturated fats, we see neutral or positive effects on inflammatory markers, blood glucose regulation, liver fat.

In fact, one of the things I tell people is if you're worried about liver fat increase from fructose, you better be worried about saturated fat because they compared them straight up equating calories overfeeding fructose versus saturated fat.

Saturated fat increased liver fat 70% more than fructose in a randomized control trial.

So again, all right, you want to make the argument that C-dols are bad for you.

You have to make the argument that saturated fat is bad for you too.

And usually it's kind of…

opposite, where they're trying to push that polyunsaturated fats are what's causing a lot of our health problems, when in reality, at every level of evidence, whether it's animal, mechanistic, human randomized control trials, or epidemiological, looking at polyunsaturated substituted for polyunsaturated, it's either neutral or positive.

I have yet to see one study

where they really show the opposite.

The one study that they'll cite is the Minnesota Coronary Experiment.

And there was some strength to that experiment.

It was, they provided all the meals to participants and they did either, you know, they were controlling their intake, either high polyunsaturated fat diet or high saturated fat diet.