Dr. Luc (Luke) van Loon

on ADT.

So the first thing that happens when they are being diagnosed with metastatic prostate cancer is that they get androgen deficiency therapy.

So basically they get chemically castrated.

So the testosterone will be gone down just completely numb.

These people generally gain fat mass, lose muscle mass, and are at a heightened risk for cardiovascular disease and often develop also insulin resistance and diabetes.

Now, we thought like, hey, how easy is it to increase or prevent the muscle loss?

To some extent, we were modest in this with only like two resistance exercise sessions a week.

We increased muscle mass.

We increased strength.

Control group went down.

There was no loss.

There was actually an increase in muscle mass.

There was an increase in muscle strength.

So the hormones do not, I'm not saying that the hormones don't play a role because hypergonadal men, of course, in general have less muscle, but exercise can fully overcome the effects of hormonal changes.

Exercise is much stronger than that.

I mean, we had a lot of, so we worked this, of course, with the department, and we worked with dialysis patients, and we worked with prostate cancer patients, and we see it every time, and everybody just says, like, why don't we just put this in our adjuvant therapy?

Like, you can go on ADT, but ADT always goes together with resistance training.

You have, I mean, the ADT is life-saving.

But then all the negative effects of the ADT can be completely, fully overcome with resistance exercise.

That's ridiculous.