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Dr. Mark D'Esposito

๐Ÿ‘ค Speaker
869 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

What I found in neurology, a lot of what patients want to know is they just want to understand their problem.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

They're not walking in expecting a cure.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

Just understanding what it is, having someone understand what happened to them is very helpful and comforting.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

What we mean by concussion, and in the clinical world we use mild traumatic brain injury kind of synonymously with concussion, it basically is a tearing of axons.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

The brain cells have these long fibers that communicate with each other, and they're called axons.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

And when the brain violently moves forward and backwards, if you're in a car accident and you have your seatbelt on and you suddenly hit, you go from 50 to 0,

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

your head violently goes forward and violently goes backwards.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

And that angular force actually tears and stretches axons in the brain.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

So if you've had a concussion, you have torn some axons.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

I mean, luckily we have billions of them.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

And so if you tear a couple of thousand, you will recover, but you have torn axons.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

It's a real neurological, it's a real brain problem.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

injury, even if you haven't lost consciousness and you've only had symptoms for a couple of days.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

And there's a correlation, the longer you've lost consciousness and the longer your symptoms last, the more axons you've torn.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

There's kind of a direct relationship between the two.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

So the mechanism is these torn axons, so now nerve cells don't communicate with each other and different brain regions are not communicating with each other.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

And it turns out the most common place for axons to tear is in the frontal lobes.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

And so now we talked about all these things that the frontal lobes do to orchestrate the rest of the brain.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

Well, it has some injured pathways.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

And that's why a lot of the symptoms that patients have are these kind of mild executive symptoms.