Dr. Mark D'Esposito

you know, these drugs are doing.

That's why the dopenerg story has been so interesting because it's a very specific effect with a very specific mechanism.

I like to see that be done with other neuromodulators.

Yeah, I think concussion is much more prevalent than we realize.

And the numbers have gone up and up, not because it's becoming more common, it's just it's becoming more recognized.

And I think, you know, we underestimated and trivialized sort of what a concussion is, you know, that it's just a...

You know, something that is, you know, just you're going to recover from it.

I mean, still the old school thinking by a lot of neurologists is that everyone gets better within a couple of months.

You know, just wait it out and you'll get better.

That's just the normal thing.

time course of concussion.

But as we've studied it more we realize that there's actually quite a large percentage of people who a year out they're still suffering problems.

They still feel like they're not mentally clear and they still are sensitive to light and they still feel a little dizzy and just the symptom you know there's a host of symptoms that just one year later after a concussion where they didn't even lose consciousness you know that's something that they may not

have even talked to their doctor about is lingering.

And so it's a real, we call this persistent post-concussion syndrome, and that's the most worrisome to me because it is true that most concussions will recover.

Luckily, the brain is incredibly resilient, incredibly plastic, and it will heal itself.

Um, but there are a lot of patients where it just, it just persists.

And those are the most worrisome to me because we don't have very good interventions to try and help that.

And I don't think we take these patients very seriously when they're complaining of something that seems very vague and not very specific to most, most doctors.

Yeah, well, first of all, I explain what a concussion is.