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Dr. Mark D'Esposito

๐Ÿ‘ค Speaker
869 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

Well, she measured their modularity on a moment-to-moment basis, and she could predict if they were going to get that, if they were going to be correct or not and wreck the sound before they got the sound.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

If they were highly modular, boom, they got it.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

If their brain had gone into this kind of diffuse, less moderate state, they missed it.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

And so I could definitely see, as you're just talking about, where if we could develop a modularity metric in real time,

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

on a device this would be game changer and so and that's sort of what i'm you know what i've been interested in do what excites me is that we're not going to do with a scan obviously you can't walk around with a scanner in your head right and and even i don't think you could even do with the eg i think can we develop a proxy for modularity with some more simple

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

way of doing it.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

Can we extract this maybe out of heart rate variability or for oxygen?

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

I've been working with some colleagues, a former student, Brian Miller, and a postdoc of Adam Gazali's, Wes Clapp, who have a company called Neuroscouting,

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

where they are able to, they have, we've been sort of doing scanning and also collecting physiological data to try and determine if there's some, we can measure the modularity in the scanner, but can we pick that up in the physiology data because they can collect

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

you know, oxygen and heart rate variability and other metrics that may be kind of a readout of that.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

And then we'd have a brain state, which is what you were looking, you know, you're looking for some brain state.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

But it's not, I think people are thinking we need a helmet or something like that.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

We need just something simple, right, that reads out brain state just the way we read out other physiological information from our watch or something like that.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

No, it's just, it has to do with how we make these measurements and connectivity doesn't mean the same, you know, there's different types of connectivity.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

And so I like to

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

When I think about connectivity, we talked about this connectivity of a brain state versus a brain trait.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

So when we're talking about you being highly modular as a trait, that's very different than what your modularity is like in different states.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

It actually turns out when you do these highly executive things,

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

demanding tasks, you get less modular because your networks are communicating with each other.

Huberman Lab
Dr. Mark D'Esposito: How to Optimize Cognitive Function & Brain Health

So it's important for networks to get less modular when it's a more demanding task.