Dr. Mark Hyman

So catabolism and anabolism, we'd like to be balanced. But that can occur, that same model can go right down to every cell type. So let's talk about molecules that we want to put a label on. Let's talk about prostaglandin E2, which we call an inflammatory molecule. So we say, oh, gee, we see a high level of that molecule in the blood if a person has a lot of inflammation.

So we want to get rid of it. How do we get rid of it? We block it with an anti-inflammatory drug like inomethacin or ibuprofen. That blocks PGE2. Now, but when we block PGE2, what happens? Then we become more immune immune. suppressed and now we become more at risk to opportunistic infection. So it's not that PGE2 is a bad molecule. It's part of a balance of one side of the road.

So we want to get rid of it. How do we get rid of it? We block it with an anti-inflammatory drug like inomethacin or ibuprofen. That blocks PGE2. Now, but when we block PGE2, what happens? Then we become more immune immune. suppressed and now we become more at risk to opportunistic infection. So it's not that PGE2 is a bad molecule. It's part of a balance of one side of the road.

So we want to get rid of it. How do we get rid of it? We block it with an anti-inflammatory drug like inomethacin or ibuprofen. That blocks PGE2. Now, but when we block PGE2, what happens? Then we become more immune immune. suppressed and now we become more at risk to opportunistic infection. So it's not that PGE2 is a bad molecule. It's part of a balance of one side of the road.

What we need is then a counterbalance on the other side of the road for PGE1. And we can do that by properly navigating the immune system into resilience. So it's balanced between PGA2 and PGE1. That's just one of a myriad of examples that we could go through in physiology.

What we need is then a counterbalance on the other side of the road for PGE1. And we can do that by properly navigating the immune system into resilience. So it's balanced between PGA2 and PGE1. That's just one of a myriad of examples that we could go through in physiology.

What we need is then a counterbalance on the other side of the road for PGE1. And we can do that by properly navigating the immune system into resilience. So it's balanced between PGA2 and PGE1. That's just one of a myriad of examples that we could go through in physiology.

So our role is to find ways of restoring that resilience so your body has that ability to go on both sides of the road simultaneously.

So our role is to find ways of restoring that resilience so your body has that ability to go on both sides of the road simultaneously.

So our role is to find ways of restoring that resilience so your body has that ability to go on both sides of the road simultaneously.

Yes.

Yes.

Yes.

We are right now, for the first time, I think, in human history, able to find some answers to that question. That's the exciting situation that we find ourselves in. So what have we learned? So let me go back, if I can, to universal learnings. historic learning.

We are right now, for the first time, I think, in human history, able to find some answers to that question. That's the exciting situation that we find ourselves in. So what have we learned? So let me go back, if I can, to universal learnings. historic learning.

We are right now, for the first time, I think, in human history, able to find some answers to that question. That's the exciting situation that we find ourselves in. So what have we learned? So let me go back, if I can, to universal learnings. historic learning.

You have done a lot in bringing up Dan Buettner's work with Blue Zones and how do they relate and you've traveled these countries and you've spoken eloquently and you've been in videos and movies and you've brought to people's understanding that certain kind of simple lifestyles were associated with increased longevity.

You have done a lot in bringing up Dan Buettner's work with Blue Zones and how do they relate and you've traveled these countries and you've spoken eloquently and you've been in videos and movies and you've brought to people's understanding that certain kind of simple lifestyles were associated with increased longevity.

You have done a lot in bringing up Dan Buettner's work with Blue Zones and how do they relate and you've traveled these countries and you've spoken eloquently and you've been in videos and movies and you've brought to people's understanding that certain kind of simple lifestyles were associated with increased longevity.

And so we started asking the question, what are the principles that kind of the through line that connect these things together that when we actually ask questions about how these things influence their immune system, we can come up with answers and those answers lead us into ways that we can employ that in our lives.