Dr. Mary Claire Haver

Do I have that correct?

And no one taught me this.

Like this was not medical school.

This was not residency.

Right.

Okay, you can't break it down.

So, you know, in the normal, this is for the audience, in a normal female biological cycle, before menopause enters the chat, we have natural undulations of these hormones.

We peak mid-cycle at ovulation for estrogen, just after ovulation, and then progesterone kind of rises after that.

In perimenopause, we lose that ability to predict what's going to happen.

And it's very, very chaotic, these changes.

So listening to women, you know, HRT doesn't fix everything, right?

And so learning about this and realizing...

how related these two, you know, the histamine levels are to hormones and how things go just chaotic in perimenopause and seeing an increase in those symptoms does make a lot of sense to me clinically from what I'm seeing in my patients.

I just didn't know how to connect the dots.

Okay.

So receptor confusion in the media has been a little bit crazy.

So H1 versus H2, can you, in layman's terms, walk us through those two receptors?

Right.

And we'll get into risk in a second.

Why do women particularly have more mast cell-related conditions than men?