Dr. Mary Claire Haver

And it actually has about a 30% strength compared to estradiol for that receptor.

So the idea that it is somehow safer doesn't actually make a lot of physiologic sense.

It's just weaker.

And so some thought can be put into, well, is it different?

Will it affect the

alpha or the beta receptor, this is really detailed.

And so people will say, well, it's better at the level of the breast, but we have good data showing that estradiol is not dangerous for the breast.

So I don't think, you know, estriol is necessarily better in that way.

Both of these are going to be a wash.

And then triest is going to be the same as, you know, the estradiol, estriol, and then you're going to throw in the estrone, which is the other form of natural estrogen that's made in menopause.

There's not good data for it.

We know that there is some inflammatory properties of just estrogen in general.

To say it's pro-inflammatory is tricky because, again, it's only acting on a receptor, right?

And there are some tissues where the estrogen receptor is pro-inflammatory.

Let's go through after puberty.

Yeah.

So I said that the ovary is where these hormones are made, but they're made actually in lots of other tissue.

I mean, there is estrogen that is made in the gut.

There's in the brain.

And then there's also estrogen that is made in adipose cells.