Dr. Mary Claire Haver

So those are fat cells.

And so that's where you're going to see the postmenopausal estrogens made.

And that's where estrone is mainly going to be made.

Estriol and estradiol are mainly made in the ovary in something called the granulosa cell, if you want to get into my science textbooks.

Lots of drama on it.

So again, we're talking about some sort of molecule that is affecting a receptor.

I think that when we talk about body identical hormones, when it comes to estrogens, that there is evidence, I would argue, that estradiol in some ways is...

It's less potent.

So you're going to see lower rates of increasing in clotting factors with it.

We have data on conjugated equine estrogen.

That's the other one that's FDA approved for things like dementia.

If you give it at an older age, that conjugated equine estrogen is probably not beneficial at an older age for dementia prevention.

And so I think that

It really is what people tolerate.

And we are now really favoring the transdermal approaches, which I just tell people, we're just mimicking what your ovaries are doing.

I get this every day.

You probably get it too, where they're like, is this risky?

And I'm like, I'm not giving you anything new.

Your body has been exposed to this hormone, you know, for decades.

And we're just replacing what your ovaries are no longer doing.