Dr. Matt Walker

Zero change in their sleep.

Because you could imagine, well, it's important to understand the mechanism here.

Is it that when you're rocking, there is, it's not just about vestibular stimulation, maybe that rocking,

sort of modestly changes friction, which changes temperature.

You could come up with all sorts of wacky reasons.

This was a very clear causal manipulation of the lateral vestibular system.

And if that is not in place, you fail to get the benefit.

So it clearly has something to do with the vestibular system.

Yeah, please.

On a central common pathway that could be the absence of... I think it's entirely possible.

In some ways, right now, we think that these two things are associated, that as you're falling asleep, gradually you will lose proprioceptive sensation.

Okay.

But...

Simply the fact that two things are associated doesn't necessarily mean they're causal, but your suggestion here is a very elegant way of testing that hypothesis, which is that perhaps if you could show that the symmetric of proprioception becomes compromised when you start doing lateral

sort of kinesthetic or movement stimulation, that's a very powerful demonstration that it's not just... So here with the study in the mice, they lacked the lateral vestibular sensation and you lost the sleep benefit.

But maybe there's one step down, which is that when you lose that vestibular stimulation, you lose the benefit on the thing that really is augmenting the sleep, which is the change in proprioception.

So this is the first step in a chain of command, and you've missed the final common transactor of that ingredient called better sleep.

And those, I would say, are probably the four current bastions of sleep augmentation.

Hopefully that describes to listeners the range of where sort of sleep 3.0, sleep enhancement 3.0 is going, and also describes...

the way in which we can come down the strata from high friction, low friction to no friction.