Dr. Matthew Hill

We say that anandamide may be more tonic and 2-AG might be more phasic and like brought online when needed, but doesn't do a lot. There is some evidence that 2-AG may also have a role to regulate some circuits under kind of resting conditions as well. And there certainly are some situations where anandamide might get brought into play. to affect plasticity, but

We say that anandamide may be more tonic and 2-AG might be more phasic and like brought online when needed, but doesn't do a lot. There is some evidence that 2-AG may also have a role to regulate some circuits under kind of resting conditions as well. And there certainly are some situations where anandamide might get brought into play. to affect plasticity, but

as kind of like an umbrella idea of how we look at it, that's often how we divide those two up. So we kind of have these two molecules. They end of the day do the same thing. They're regulating neurotransmitter release through retrograde signaling. But what stimulation brings them online or what drives their activity may differentiate.

as kind of like an umbrella idea of how we look at it, that's often how we divide those two up. So we kind of have these two molecules. They end of the day do the same thing. They're regulating neurotransmitter release through retrograde signaling. But what stimulation brings them online or what drives their activity may differentiate.

as kind of like an umbrella idea of how we look at it, that's often how we divide those two up. So we kind of have these two molecules. They end of the day do the same thing. They're regulating neurotransmitter release through retrograde signaling. But what stimulation brings them online or what drives their activity may differentiate.

And we don't really understand all the details behind that, outside of the fact that we very clearly know 2-AG is activity dependent. So as that neuron becomes more active, it's going to make 2-AG to regulate its inputs. So, yeah, you have this very complex system, and it's really widely distributed in, you know, it's everywhere.

And we don't really understand all the details behind that, outside of the fact that we very clearly know 2-AG is activity dependent. So as that neuron becomes more active, it's going to make 2-AG to regulate its inputs. So, yeah, you have this very complex system, and it's really widely distributed in, you know, it's everywhere.

And we don't really understand all the details behind that, outside of the fact that we very clearly know 2-AG is activity dependent. So as that neuron becomes more active, it's going to make 2-AG to regulate its inputs. So, yeah, you have this very complex system, and it's really widely distributed in, you know, it's everywhere.

The cannabinoid receptors in the endocannabinoid molecules are in the cortex, they're in the hypothalamus, they're in the striatum, the hippocampus, the cerebellum. All over the brain. Except the one area where it's really interesting, actually, where you don't really see much receptor is in brainstem populations that regulate, you know, kind of unconscious cardiac and respiratory function.

The cannabinoid receptors in the endocannabinoid molecules are in the cortex, they're in the hypothalamus, they're in the striatum, the hippocampus, the cerebellum. All over the brain. Except the one area where it's really interesting, actually, where you don't really see much receptor is in brainstem populations that regulate, you know, kind of unconscious cardiac and respiratory function.

The cannabinoid receptors in the endocannabinoid molecules are in the cortex, they're in the hypothalamus, they're in the striatum, the hippocampus, the cerebellum. All over the brain. Except the one area where it's really interesting, actually, where you don't really see much receptor is in brainstem populations that regulate, you know, kind of unconscious cardiac and respiratory function.

So this is one of the things that really differentiates cannabis from opiates because a lot of the signaling mechanisms between opioid receptors and cannabinoid receptors are quite similar. But as it's been well established, people can overdose fatally and die from opiates relatively easily.

So this is one of the things that really differentiates cannabis from opiates because a lot of the signaling mechanisms between opioid receptors and cannabinoid receptors are quite similar. But as it's been well established, people can overdose fatally and die from opiates relatively easily.

So this is one of the things that really differentiates cannabis from opiates because a lot of the signaling mechanisms between opioid receptors and cannabinoid receptors are quite similar. But as it's been well established, people can overdose fatally and die from opiates relatively easily.

And the way that that tends to happen is when you activate the opiate receptors in the kind of cardiorespiratory parts of the brainstem, it depresses neural activity. So as the person loses consciousness... they also unconsciously will stop regulating their own heart and breathing, and it can be a fatal response.

And the way that that tends to happen is when you activate the opiate receptors in the kind of cardiorespiratory parts of the brainstem, it depresses neural activity. So as the person loses consciousness... they also unconsciously will stop regulating their own heart and breathing, and it can be a fatal response.

And the way that that tends to happen is when you activate the opiate receptors in the kind of cardiorespiratory parts of the brainstem, it depresses neural activity. So as the person loses consciousness... they also unconsciously will stop regulating their own heart and breathing, and it can be a fatal response.

Because cannabinoid receptors don't really exist in those regions, you don't get the same kind of impact in terms of suppressing heart rate and breathing function. And so that's, I mean... There's always the saying, there's never been an account of someone actually dying from a cannabis overdose or a THC overdose.

Because cannabinoid receptors don't really exist in those regions, you don't get the same kind of impact in terms of suppressing heart rate and breathing function. And so that's, I mean... There's always the saying, there's never been an account of someone actually dying from a cannabis overdose or a THC overdose.

Because cannabinoid receptors don't really exist in those regions, you don't get the same kind of impact in terms of suppressing heart rate and breathing function. And so that's, I mean... There's always the saying, there's never been an account of someone actually dying from a cannabis overdose or a THC overdose.