Dr. Matthew Hill

I mean, certainly people can do stupid things while they're intoxicated that result in their death. But in the same manner that someone can die from consuming too much opiates, that doesn't seem to be physically possible with cannabinoids as far as we've seen so far. And a lot of that is just because of the localization. For some reason, it's just not the receptors in that part of the brain. Cool.

I mean, certainly people can do stupid things while they're intoxicated that result in their death. But in the same manner that someone can die from consuming too much opiates, that doesn't seem to be physically possible with cannabinoids as far as we've seen so far. And a lot of that is just because of the localization. For some reason, it's just not the receptors in that part of the brain. Cool.

I mean, certainly people can do stupid things while they're intoxicated that result in their death. But in the same manner that someone can die from consuming too much opiates, that doesn't seem to be physically possible with cannabinoids as far as we've seen so far. And a lot of that is just because of the localization. For some reason, it's just not the receptors in that part of the brain. Cool.

So, yeah, if you go back to the munchies question you had. So if we tie into that, one of the – so there's a few ways. I mean cannabinoids in feeding are a really interesting thing because proto – like if you ask people like kind of the prototypical responses to consuming cannabis, most people would usually say munchies is one of the things that pops up pretty regularly. And so –

So, yeah, if you go back to the munchies question you had. So if we tie into that, one of the – so there's a few ways. I mean cannabinoids in feeding are a really interesting thing because proto – like if you ask people like kind of the prototypical responses to consuming cannabis, most people would usually say munchies is one of the things that pops up pretty regularly. And so –

So, yeah, if you go back to the munchies question you had. So if we tie into that, one of the – so there's a few ways. I mean cannabinoids in feeding are a really interesting thing because proto – like if you ask people like kind of the prototypical responses to consuming cannabis, most people would usually say munchies is one of the things that pops up pretty regularly. And so –

you know, the cannabinoid receptors are very, um, they are expressed in these feeding circuits in the hypothalamus. Um, and you know, there's a lot of complex circuitry there that can regulate food seeking behavior.

you know, the cannabinoid receptors are very, um, they are expressed in these feeding circuits in the hypothalamus. Um, and you know, there's a lot of complex circuitry there that can regulate food seeking behavior.

you know, the cannabinoid receptors are very, um, they are expressed in these feeding circuits in the hypothalamus. Um, and you know, there's a lot of complex circuitry there that can regulate food seeking behavior.

And so we know that cannabinoids, they regulate, again, those inhibitory inputs around AGRP neurons, for example. And so one thing they can do is disinhibit those AGRP neurons so they become more active and that can drive food-seeking behavior. So that's certainly one mechanism of it. But there's also a huge reward component to this in terms of the munchies. And so...

And so we know that cannabinoids, they regulate, again, those inhibitory inputs around AGRP neurons, for example. And so one thing they can do is disinhibit those AGRP neurons so they become more active and that can drive food-seeking behavior. So that's certainly one mechanism of it. But there's also a huge reward component to this in terms of the munchies. And so...

And so we know that cannabinoids, they regulate, again, those inhibitory inputs around AGRP neurons, for example. And so one thing they can do is disinhibit those AGRP neurons so they become more active and that can drive food-seeking behavior. So that's certainly one mechanism of it. But there's also a huge reward component to this in terms of the munchies. And so...

We know that like you can also just dump anandamide, for example. This is, you know, Steve Mahler and Kent Barrage did this work years ago where they just put anandamide into the nucleus accumbens, and that can also stimulate palatable food intake. So you also have this ability to integrate with the reward circuitry.

We know that like you can also just dump anandamide, for example. This is, you know, Steve Mahler and Kent Barrage did this work years ago where they just put anandamide into the nucleus accumbens, and that can also stimulate palatable food intake. So you also have this ability to integrate with the reward circuitry.

We know that like you can also just dump anandamide, for example. This is, you know, Steve Mahler and Kent Barrage did this work years ago where they just put anandamide into the nucleus accumbens, and that can also stimulate palatable food intake. So you also have this ability to integrate with the reward circuitry.

And then there was also this fascinating paper from a Japanese group in PNAS, I think about 12 years ago. And what they found was they would give a rodent And then they would stimulate different taste bud populations. And then they would look at the gustatory cortical response to stimulating the populations.

And then there was also this fascinating paper from a Japanese group in PNAS, I think about 12 years ago. And what they found was they would give a rodent And then they would stimulate different taste bud populations. And then they would look at the gustatory cortical response to stimulating the populations.

And then there was also this fascinating paper from a Japanese group in PNAS, I think about 12 years ago. And what they found was they would give a rodent And then they would stimulate different taste bud populations. And then they would look at the gustatory cortical response to stimulating the populations.

And what they found is under the influence of a cannabinoid, if you stimulated sweet taste buds, you got an enhanced response in the gustatory cortex. not if you did salty, bitter, or sour, or I don't know if they did umami in that one, but it was very explicit to sweet tasting. And so you have this kind of ability to like jack up the way the brain is processing sweet tasting foods.

And what they found is under the influence of a cannabinoid, if you stimulated sweet taste buds, you got an enhanced response in the gustatory cortex. not if you did salty, bitter, or sour, or I don't know if they did umami in that one, but it was very explicit to sweet tasting. And so you have this kind of ability to like jack up the way the brain is processing sweet tasting foods.