Dr. Matthew Hill

And what they found is under the influence of a cannabinoid, if you stimulated sweet taste buds, you got an enhanced response in the gustatory cortex. not if you did salty, bitter, or sour, or I don't know if they did umami in that one, but it was very explicit to sweet tasting. And so you have this kind of ability to like jack up the way the brain is processing sweet tasting foods.

You have this engagement of the reward circuitry, and then you also have this ability to regulate AGRP neurons as well as the POMC neurons. There's kind of both sides to that in the arcuate nucleus to regulate multiple components of feeding. But A big question is like my lab has become kind of interested in this as well because we have a component of my lab that studies feeding behavior.

You have this engagement of the reward circuitry, and then you also have this ability to regulate AGRP neurons as well as the POMC neurons. There's kind of both sides to that in the arcuate nucleus to regulate multiple components of feeding. But A big question is like my lab has become kind of interested in this as well because we have a component of my lab that studies feeding behavior.

You have this engagement of the reward circuitry, and then you also have this ability to regulate AGRP neurons as well as the POMC neurons. There's kind of both sides to that in the arcuate nucleus to regulate multiple components of feeding. But A big question is like my lab has become kind of interested in this as well because we have a component of my lab that studies feeding behavior.

And one of my postdocs has been doing these projects for years now trying to understand almost like at a behavioral mechanism level what the munchies are. And what she's been looking at is we kind of started thinking about the idea that, you know, what is it that – because it's not just food seeking and it's not just – you know, like just want to consume something, there's a maintenance of eating.

And one of my postdocs has been doing these projects for years now trying to understand almost like at a behavioral mechanism level what the munchies are. And what she's been looking at is we kind of started thinking about the idea that, you know, what is it that – because it's not just food seeking and it's not just – you know, like just want to consume something, there's a maintenance of eating.

And one of my postdocs has been doing these projects for years now trying to understand almost like at a behavioral mechanism level what the munchies are. And what she's been looking at is we kind of started thinking about the idea that, you know, what is it that – because it's not just food seeking and it's not just – you know, like just want to consume something, there's a maintenance of eating.

And so we know from humans and animals, you can satiate them. You can make someone full and then get them high on cannabis and they'll reinitiate eating. So that's an interesting thing in and of itself, because that means you're disrupting either the ability of the brain to detect satiety or you're messing with a process we call reward devaluation.

And so we know from humans and animals, you can satiate them. You can make someone full and then get them high on cannabis and they'll reinitiate eating. So that's an interesting thing in and of itself, because that means you're disrupting either the ability of the brain to detect satiety or you're messing with a process we call reward devaluation.

And so we know from humans and animals, you can satiate them. You can make someone full and then get them high on cannabis and they'll reinitiate eating. So that's an interesting thing in and of itself, because that means you're disrupting either the ability of the brain to detect satiety or you're messing with a process we call reward devaluation.

And so reward devaluation is like if you haven't eaten for a day and you see like a picture of a pizza or someone brings a pizza in front of you, it just looks delicious. And that first slice tastes amazing. It's salty. It's fatty. It's delicious. You eat five of those slices, it feels greasy and nasty.

And so reward devaluation is like if you haven't eaten for a day and you see like a picture of a pizza or someone brings a pizza in front of you, it just looks delicious. And that first slice tastes amazing. It's salty. It's fatty. It's delicious. You eat five of those slices, it feels greasy and nasty.

And so reward devaluation is like if you haven't eaten for a day and you see like a picture of a pizza or someone brings a pizza in front of you, it just looks delicious. And that first slice tastes amazing. It's salty. It's fatty. It's delicious. You eat five of those slices, it feels greasy and nasty.

And so that process of how you perceive the food and its reward salience degrades as you eat and as your brain basically – shifts into a thing of we don't need to consume calories and food anymore. We're okay. We're full now.

And so that process of how you perceive the food and its reward salience degrades as you eat and as your brain basically – shifts into a thing of we don't need to consume calories and food anymore. We're okay. We're full now.

And so that process of how you perceive the food and its reward salience degrades as you eat and as your brain basically – shifts into a thing of we don't need to consume calories and food anymore. We're okay. We're full now.

And so we've done a series of experiments in the lab where you'd get the animals and either satiate it in advance where they have already devalued the food and under a normal state, they won't eat it anymore. They won't work to get access to it. And you get them high on like a cannabis extract.

And so we've done a series of experiments in the lab where you'd get the animals and either satiate it in advance where they have already devalued the food and under a normal state, they won't eat it anymore. They won't work to get access to it. And you get them high on like a cannabis extract.

And so we've done a series of experiments in the lab where you'd get the animals and either satiate it in advance where they have already devalued the food and under a normal state, they won't eat it anymore. They won't work to get access to it. And you get them high on like a cannabis extract.

We have these vape chambers that are like, I don't know how else to describe it outside of like a little hot box. It's probably the best way to, because it's essentially a kind of a, a locked airtight box that the rack goes in and it gets like vapor puffs and it fills up and then they inhale this and then it clears out and they get another puff and then it fills up.