Dr. Matthew Hill

We have these vape chambers that are like, I don't know how else to describe it outside of like a little hot box. It's probably the best way to, because it's essentially a kind of a, a locked airtight box that the rack goes in and it gets like vapor puffs and it fills up and then they inhale this and then it clears out and they get another puff and then it fills up.

We have these vape chambers that are like, I don't know how else to describe it outside of like a little hot box. It's probably the best way to, because it's essentially a kind of a, a locked airtight box that the rack goes in and it gets like vapor puffs and it fills up and then they inhale this and then it clears out and they get another puff and then it fills up.

And we do this for like 15 minutes and we've titrated all this to get exactly blood levels of THC that you would achieve in someone who's, you know, consuming cannabis through smoking. Um, and so we get them to that point and then give them access to food and they will You know, go gangbusters. They eat food. Doesn't matter what you give them. You give them plain chow. They go to town.

And we do this for like 15 minutes and we've titrated all this to get exactly blood levels of THC that you would achieve in someone who's, you know, consuming cannabis through smoking. Um, and so we get them to that point and then give them access to food and they will You know, go gangbusters. They eat food. Doesn't matter what you give them. You give them plain chow. They go to town.

And we do this for like 15 minutes and we've titrated all this to get exactly blood levels of THC that you would achieve in someone who's, you know, consuming cannabis through smoking. Um, and so we get them to that point and then give them access to food and they will You know, go gangbusters. They eat food. Doesn't matter what you give them. You give them plain chow. They go to town.

You give them fatty. You give them sweet. They love it all. But you presatiate them and they get them stoned. They will reinitiate eating again. And you make them work for it where they have to, like, lever press. And you get them stoned and they will go to town on that and they will work.

You give them fatty. You give them sweet. They love it all. But you presatiate them and they get them stoned. They will reinitiate eating again. And you make them work for it where they have to, like, lever press. And you get them stoned and they will go to town on that and they will work.

You give them fatty. You give them sweet. They love it all. But you presatiate them and they get them stoned. They will reinitiate eating again. And you make them work for it where they have to, like, lever press. And you get them stoned and they will go to town on that and they will work.

Yeah, they, for food, I don't know about other stuff, but for food, they certainly will. I mean, and at least Wiertz and Cassie Moore have done this at Hopkins as well. They've shown similarly using what we call progressive ratio, which is essentially a thing where it's like the first time you press a lever, you immediately get a sugar. Next time you got to hit it twice to get a pellet.

Yeah, they, for food, I don't know about other stuff, but for food, they certainly will. I mean, and at least Wiertz and Cassie Moore have done this at Hopkins as well. They've shown similarly using what we call progressive ratio, which is essentially a thing where it's like the first time you press a lever, you immediately get a sugar. Next time you got to hit it twice to get a pellet.

Yeah, they, for food, I don't know about other stuff, but for food, they certainly will. I mean, and at least Wiertz and Cassie Moore have done this at Hopkins as well. They've shown similarly using what we call progressive ratio, which is essentially a thing where it's like the first time you press a lever, you immediately get a sugar. Next time you got to hit it twice to get a pellet.

Then you have to hit it four times to get one. That's like life. Yeah, then you got to hit it 16 and then it kind of scales exponentially up. I mean, we've had this one female we kind of joke about in the lab, this one female rat, and you get her high and she'll do like 300 lever presses to get one sugar pelt. Like she really wants it. So you can really kind of goose up their motivation to eat.

Then you have to hit it four times to get one. That's like life. Yeah, then you got to hit it 16 and then it kind of scales exponentially up. I mean, we've had this one female we kind of joke about in the lab, this one female rat, and you get her high and she'll do like 300 lever presses to get one sugar pelt. Like she really wants it. So you can really kind of goose up their motivation to eat.

Then you have to hit it four times to get one. That's like life. Yeah, then you got to hit it 16 and then it kind of scales exponentially up. I mean, we've had this one female we kind of joke about in the lab, this one female rat, and you get her high and she'll do like 300 lever presses to get one sugar pelt. Like she really wants it. So you can really kind of goose up their motivation to eat.

And so there's clearly a rewarding aspect of this. because they're motivated to engage enough in working to get access to the food. But you can also do another way of testing this question, which is you can pair a food with something that will make the animal feel nauseous, like lithium chloride. This is kind of the way that you would test conditioned taste aversion.

And so there's clearly a rewarding aspect of this. because they're motivated to engage enough in working to get access to the food. But you can also do another way of testing this question, which is you can pair a food with something that will make the animal feel nauseous, like lithium chloride. This is kind of the way that you would test conditioned taste aversion.

And so there's clearly a rewarding aspect of this. because they're motivated to engage enough in working to get access to the food. But you can also do another way of testing this question, which is you can pair a food with something that will make the animal feel nauseous, like lithium chloride. This is kind of the way that you would test conditioned taste aversion.

So you give them access to a food, and then you give them something that makes them feel nauseous, and the animals will avoid that food. And so that's another way to kind of devalue a food is by pairing it with a nauseant so the animal no longer likes it.

So you give them access to a food, and then you give them something that makes them feel nauseous, and the animals will avoid that food. And so that's another way to kind of devalue a food is by pairing it with a nauseant so the animal no longer likes it.

So you give them access to a food, and then you give them something that makes them feel nauseous, and the animals will avoid that food. And so that's another way to kind of devalue a food is by pairing it with a nauseant so the animal no longer likes it.