Dr. Matthew Hill

And so you can prevent these anorectic effects of leptin by like goosing up endocannabinoid activity. Yeah.

Yes. I mean, they dynamically change all the time.

Yes. I mean, they dynamically change all the time.

Yes. I mean, they dynamically change all the time.

So, okay. A few things there. We'll take a step back. So THC itself isn't going to – it does its thing by –

So, okay. A few things there. We'll take a step back. So THC itself isn't going to – it does its thing by –

So, okay. A few things there. We'll take a step back. So THC itself isn't going to – it does its thing by –

Yeah. So THC, going back to kind of the pharmacology of this. So THC, if you look at how it interacts with the receptor, it's... It's not a heavy duty molecule. So, I mean, this was kind of one of the things that came up before as well, is this idea that THC is a sledgehammer and it overrides endocannabinoids.

Yeah. So THC, going back to kind of the pharmacology of this. So THC, if you look at how it interacts with the receptor, it's... It's not a heavy duty molecule. So, I mean, this was kind of one of the things that came up before as well, is this idea that THC is a sledgehammer and it overrides endocannabinoids.

Yeah. So THC, going back to kind of the pharmacology of this. So THC, if you look at how it interacts with the receptor, it's... It's not a heavy duty molecule. So, I mean, this was kind of one of the things that came up before as well, is this idea that THC is a sledgehammer and it overrides endocannabinoids.

Yeah. I mean, you don't really actually need much THC in the brain to produce psychoactivity. It's a little bit of a mystery, to be honest, exactly how it works. I mean, I think the main... way that most people in the cannabinoid theory field would look at this is that THC is not like a very strong agonist.

Yeah. I mean, you don't really actually need much THC in the brain to produce psychoactivity. It's a little bit of a mystery, to be honest, exactly how it works. I mean, I think the main... way that most people in the cannabinoid theory field would look at this is that THC is not like a very strong agonist.

Yeah. I mean, you don't really actually need much THC in the brain to produce psychoactivity. It's a little bit of a mystery, to be honest, exactly how it works. I mean, I think the main... way that most people in the cannabinoid theory field would look at this is that THC is not like a very strong agonist.

I mean, even if you look at its ability to trigger an intracellular response, it's much lower than 2-AG. It's actually more like anandamide.

I mean, even if you look at its ability to trigger an intracellular response, it's much lower than 2-AG. It's actually more like anandamide.

I mean, even if you look at its ability to trigger an intracellular response, it's much lower than 2-AG. It's actually more like anandamide.

Yeah, so THC is the same. THC is actually only a partial agonist. It's not even a full agonist at CB1.

Yeah, so THC is the same. THC is actually only a partial agonist. It's not even a full agonist at CB1.

Yeah, so THC is the same. THC is actually only a partial agonist. It's not even a full agonist at CB1.

It's high affinity. So it has the ability... But the tricky thing with that is... It can out-compete 2-AG, but because it's a lower efficacy agonist than 2-AG, in that sense, it's almost blocking the effects, not amplifying them.