Dr. Matthew Hill

And so when we boost anandamide signaling by inhibiting its metabolism, all we're doing is amplifying anandamide signaling at the synapses it already exists. Whereas THC, when you consume it orally or inhalation-wise and it gets into your blood and into your brain, it's just blanket activation. You're just carpet bombing the whole system indiscriminately.

And so when we boost anandamide signaling by inhibiting its metabolism, all we're doing is amplifying anandamide signaling at the synapses it already exists. Whereas THC, when you consume it orally or inhalation-wise and it gets into your blood and into your brain, it's just blanket activation. You're just carpet bombing the whole system indiscriminately.

I think the problem is when you just blanket activate all the CB1 receptors in the brain indiscriminately, like you do when you consume cannabis with THC, the resulting effect is the intoxicating state.

I think the problem is when you just blanket activate all the CB1 receptors in the brain indiscriminately, like you do when you consume cannabis with THC, the resulting effect is the intoxicating state.

I think the problem is when you just blanket activate all the CB1 receptors in the brain indiscriminately, like you do when you consume cannabis with THC, the resulting effect is the intoxicating state.

And it's probably because there's a lot of CB1 receptors in the cortex, and those are going to be differentially regulated at different times by endocannabinoids, whereas when THC hits them, all of them are going to get affected at once. And if you think of the way that

And it's probably because there's a lot of CB1 receptors in the cortex, and those are going to be differentially regulated at different times by endocannabinoids, whereas when THC hits them, all of them are going to get affected at once. And if you think of the way that

And it's probably because there's a lot of CB1 receptors in the cortex, and those are going to be differentially regulated at different times by endocannabinoids, whereas when THC hits them, all of them are going to get affected at once. And if you think of the way that

I had described how cannabinoid receptors work by essentially – I mean, in its simplest form, what cannabinoid receptors do is they change the way that two neurons talk to each other. And so – So you're changing all the networks simultaneously. Yeah. So if you hit a whole bunch of networks simultaneously, you're just going to change the way that information processing and perception occurs.

I had described how cannabinoid receptors work by essentially – I mean, in its simplest form, what cannabinoid receptors do is they change the way that two neurons talk to each other. And so – So you're changing all the networks simultaneously. Yeah. So if you hit a whole bunch of networks simultaneously, you're just going to change the way that information processing and perception occurs.

I had described how cannabinoid receptors work by essentially – I mean, in its simplest form, what cannabinoid receptors do is they change the way that two neurons talk to each other. And so – So you're changing all the networks simultaneously. Yeah. So if you hit a whole bunch of networks simultaneously, you're just going to change the way that information processing and perception occurs.

And I think as a consequence of that, that's what produces the intoxicating state, not that THC is – like a super duper version of an endocannabinoid or that it's boosting endocannabinoids. It's kind of like... just indiscriminately activating all the receptors as opposed to a system that's very finely tuned to do very specific things at very specific times.

And I think as a consequence of that, that's what produces the intoxicating state, not that THC is – like a super duper version of an endocannabinoid or that it's boosting endocannabinoids. It's kind of like... just indiscriminately activating all the receptors as opposed to a system that's very finely tuned to do very specific things at very specific times.

And I think as a consequence of that, that's what produces the intoxicating state, not that THC is – like a super duper version of an endocannabinoid or that it's boosting endocannabinoids. It's kind of like... just indiscriminately activating all the receptors as opposed to a system that's very finely tuned to do very specific things at very specific times.

Yeah, this is a lot more to do with just, yeah, the nature of how it hits everything because... Like, so for example, if we talk about feeding, we know it's been established at this point that, for example, if an organism doesn't eat for like a day, so you fasted. At that point, in those feeding circuits in your brain, like the arcuate area where these AGRP neurons and stuff are,

Yeah, this is a lot more to do with just, yeah, the nature of how it hits everything because... Like, so for example, if we talk about feeding, we know it's been established at this point that, for example, if an organism doesn't eat for like a day, so you fasted. At that point, in those feeding circuits in your brain, like the arcuate area where these AGRP neurons and stuff are,

Yeah, this is a lot more to do with just, yeah, the nature of how it hits everything because... Like, so for example, if we talk about feeding, we know it's been established at this point that, for example, if an organism doesn't eat for like a day, so you fasted. At that point, in those feeding circuits in your brain, like the arcuate area where these AGRP neurons and stuff are,

you'll start seeing elevations in endocannabinoids. So endocannabinoid levels start kind of going up and up following kind of fasting periods. And part of this is because they're trying to engage that feeding circuitry now, and they're shifting the activity of those neurons to promote food-seeking behavior. Because an organism is basically like

you'll start seeing elevations in endocannabinoids. So endocannabinoid levels start kind of going up and up following kind of fasting periods. And part of this is because they're trying to engage that feeding circuitry now, and they're shifting the activity of those neurons to promote food-seeking behavior. Because an organism is basically like

you'll start seeing elevations in endocannabinoids. So endocannabinoid levels start kind of going up and up following kind of fasting periods. And part of this is because they're trying to engage that feeding circuitry now, and they're shifting the activity of those neurons to promote food-seeking behavior. Because an organism is basically like