Dr. Matthew Hill

energy detecting its periphery and saying, oh, you know, we might be burning through our energy reserves. We should probably eat more. And so there are obviously a few mechanisms that do this. NPY is another one and ghrelin and things like that. So there's a lot of redundancy in these systems, but endocannabinoids are just one of the molecules that seem to fine tune like the feeding circuitry.

energy detecting its periphery and saying, oh, you know, we might be burning through our energy reserves. We should probably eat more. And so there are obviously a few mechanisms that do this. NPY is another one and ghrelin and things like that. So there's a lot of redundancy in these systems, but endocannabinoids are just one of the molecules that seem to fine tune like the feeding circuitry.

energy detecting its periphery and saying, oh, you know, we might be burning through our energy reserves. We should probably eat more. And so there are obviously a few mechanisms that do this. NPY is another one and ghrelin and things like that. So there's a lot of redundancy in these systems, but endocannabinoids are just one of the molecules that seem to fine tune like the feeding circuitry.

And so in states of fasting, endocannabinoids go up explicitly in that circuit. And there's some evidence they also go up in like the nucleus accumbens and affect some of the reward circuitry. So they're probably... driving food-seeking behavior and enhancing the rewarding aspects of food at the same time.

And so in states of fasting, endocannabinoids go up explicitly in that circuit. And there's some evidence they also go up in like the nucleus accumbens and affect some of the reward circuitry. So they're probably... driving food-seeking behavior and enhancing the rewarding aspects of food at the same time.

And so in states of fasting, endocannabinoids go up explicitly in that circuit. And there's some evidence they also go up in like the nucleus accumbens and affect some of the reward circuitry. So they're probably... driving food-seeking behavior and enhancing the rewarding aspects of food at the same time.

And so that's like a natural endogenous mechanism to regulate feeding based on nutritional state. THC, on the other hand, you know, it hits the brain. Yes, some of it's going to be the intoxication, but in tandem, you're going to hit the CB1 receptors that are in those feeding circuits as well. And the consequence of that is going to be...

And so that's like a natural endogenous mechanism to regulate feeding based on nutritional state. THC, on the other hand, you know, it hits the brain. Yes, some of it's going to be the intoxication, but in tandem, you're going to hit the CB1 receptors that are in those feeding circuits as well. And the consequence of that is going to be...

And so that's like a natural endogenous mechanism to regulate feeding based on nutritional state. THC, on the other hand, you know, it hits the brain. Yes, some of it's going to be the intoxication, but in tandem, you're going to hit the CB1 receptors that are in those feeding circuits as well. And the consequence of that is going to be...

I mean, the way I kind of analogize it to people is I say it's almost like tricking the brain into thinking that you've been fasting because you're now activating receptors that are normally activated following kind of a fasting state.

I mean, the way I kind of analogize it to people is I say it's almost like tricking the brain into thinking that you've been fasting because you're now activating receptors that are normally activated following kind of a fasting state.

I mean, the way I kind of analogize it to people is I say it's almost like tricking the brain into thinking that you've been fasting because you're now activating receptors that are normally activated following kind of a fasting state.

And as a consequence of that, it pushes someone or an organism or human or whatever into a state of food-seeking behavior because now food also has high reward value and they're kind of – the way their food circuitry is responding in the brain at least seems to be similar to what would happen if they've been fasted.

And as a consequence of that, it pushes someone or an organism or human or whatever into a state of food-seeking behavior because now food also has high reward value and they're kind of – the way their food circuitry is responding in the brain at least seems to be similar to what would happen if they've been fasted.

And as a consequence of that, it pushes someone or an organism or human or whatever into a state of food-seeking behavior because now food also has high reward value and they're kind of – the way their food circuitry is responding in the brain at least seems to be similar to what would happen if they've been fasted.

And the thought is that's why when people, you know, when someone gets stoned, they're not like going to eat lettuce. They want high calorie food. They tend to like things that are high carb, high fat. That combo seems to be what people like when they're intoxicated with cannabis. And that comes with a lot of calories. And the point of that would be you're trying to replenish lost energy stores.

And the thought is that's why when people, you know, when someone gets stoned, they're not like going to eat lettuce. They want high calorie food. They tend to like things that are high carb, high fat. That combo seems to be what people like when they're intoxicated with cannabis. And that comes with a lot of calories. And the point of that would be you're trying to replenish lost energy stores.

And the thought is that's why when people, you know, when someone gets stoned, they're not like going to eat lettuce. They want high calorie food. They tend to like things that are high carb, high fat. That combo seems to be what people like when they're intoxicated with cannabis. And that comes with a lot of calories. And the point of that would be you're trying to replenish lost energy stores.

And so This at least is the kind of the theory that I have about what it is that it's doing is, you know, and I think you can make this analogy for multiple different things.

And so This at least is the kind of the theory that I have about what it is that it's doing is, you know, and I think you can make this analogy for multiple different things.