Dr. Matthew Hill

Now, if you look at the blood levels these produce, we're now talking blood levels of two to five nanograms per mil. So folds lower than what you get from inhalation. Before you said 100. Yeah. So this is dramatically lower. And so- Also, the time course of this is fundamentally different. So oral consumption, you know, you're looking at a minimum of 30 to 45 minutes for onset of intoxication.

Now, if you look at the blood levels these produce, we're now talking blood levels of two to five nanograms per mil. So folds lower than what you get from inhalation. Before you said 100. Yeah. So this is dramatically lower. And so- Also, the time course of this is fundamentally different. So oral consumption, you know, you're looking at a minimum of 30 to 45 minutes for onset of intoxication.

For some people, up to 90 minutes after they've eaten. Now, this is also the reason why... The majority of adverse events that happen with cannabis happen with edibles because people don't understand this. And so they eat a cookie or a gummy. They wait half an hour like, I'm not feeling anything. I clearly didn't take enough. And then they'll double their dose.

For some people, up to 90 minutes after they've eaten. Now, this is also the reason why... The majority of adverse events that happen with cannabis happen with edibles because people don't understand this. And so they eat a cookie or a gummy. They wait half an hour like, I'm not feeling anything. I clearly didn't take enough. And then they'll double their dose.

For some people, up to 90 minutes after they've eaten. Now, this is also the reason why... The majority of adverse events that happen with cannabis happen with edibles because people don't understand this. And so they eat a cookie or a gummy. They wait half an hour like, I'm not feeling anything. I clearly didn't take enough. And then they'll double their dose.

And then like 15 minutes later, it starts hitting them. And then like once it fully kicks in, it's just like a steamroller.

And then like 15 minutes later, it starts hitting them. And then like once it fully kicks in, it's just like a steamroller.

And then like 15 minutes later, it starts hitting them. And then like once it fully kicks in, it's just like a steamroller.

Yeah. Yeah. I mean, there was that New York, I think it was Maureen Dowder, someone went down to Colorado and she ate like an insane amount of THC in a chocolate bar, something like 50 or 100 milligrams and spent like the weekend on the floor of a hotel room being like, this was the most aversive experience. Why would anyone do this?

Yeah. Yeah. I mean, there was that New York, I think it was Maureen Dowder, someone went down to Colorado and she ate like an insane amount of THC in a chocolate bar, something like 50 or 100 milligrams and spent like the weekend on the floor of a hotel room being like, this was the most aversive experience. Why would anyone do this?

Yeah. Yeah. I mean, there was that New York, I think it was Maureen Dowder, someone went down to Colorado and she ate like an insane amount of THC in a chocolate bar, something like 50 or 100 milligrams and spent like the weekend on the floor of a hotel room being like, this was the most aversive experience. Why would anyone do this?

And again, I think people just don't understand the dosing around this. And so This is one of the things we're trying to do in Canada, and I was creating this idea of standardized dosing units so that people have an – like we do with alcohol.

And again, I think people just don't understand the dosing around this. And so This is one of the things we're trying to do in Canada, and I was creating this idea of standardized dosing units so that people have an – like we do with alcohol.

And again, I think people just don't understand the dosing around this. And so This is one of the things we're trying to do in Canada, and I was creating this idea of standardized dosing units so that people have an – like we do with alcohol.

We always say one beer is the equivalent to one glass of wine versus a shot of tequila or something so that there's some comparator that people understand how many drinks are – two drinks you do, you're going to hit legal limit kind of thing. Yeah, it seems very important. Yeah.

We always say one beer is the equivalent to one glass of wine versus a shot of tequila or something so that there's some comparator that people understand how many drinks are – two drinks you do, you're going to hit legal limit kind of thing. Yeah, it seems very important. Yeah.

We always say one beer is the equivalent to one glass of wine versus a shot of tequila or something so that there's some comparator that people understand how many drinks are – two drinks you do, you're going to hit legal limit kind of thing. Yeah, it seems very important. Yeah.

And so this is very difficult to do with cannabis because the dosing with oral consumption is just a different ballgame than it is with inhalation. But what happens with oral consumption is like it kind of very slowly leaks out of the GI tract. And it also goes through first pass metabolism in the liver. And what happens there is you get a metabolite called 11-hydroxy-THC, which –

And so this is very difficult to do with cannabis because the dosing with oral consumption is just a different ballgame than it is with inhalation. But what happens with oral consumption is like it kind of very slowly leaks out of the GI tract. And it also goes through first pass metabolism in the liver. And what happens there is you get a metabolite called 11-hydroxy-THC, which –

And so this is very difficult to do with cannabis because the dosing with oral consumption is just a different ballgame than it is with inhalation. But what happens with oral consumption is like it kind of very slowly leaks out of the GI tract. And it also goes through first pass metabolism in the liver. And what happens there is you get a metabolite called 11-hydroxy-THC, which –