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Dr. Matthew Hill

๐Ÿ‘ค Speaker
1842 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Seems to be a bit more potent than THC is in terms of its ability to activate the receptor. So its efficacy, at least, at driving a response through CB1 receptors seems to be higher than what you would get with just the parent molecule of THC itself. And... So, and it seems to accumulate a lot more as well.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Seems to be a bit more potent than THC is in terms of its ability to activate the receptor. So its efficacy, at least, at driving a response through CB1 receptors seems to be higher than what you would get with just the parent molecule of THC itself. And... So, and it seems to accumulate a lot more as well.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Seems to be a bit more potent than THC is in terms of its ability to activate the receptor. So its efficacy, at least, at driving a response through CB1 receptors seems to be higher than what you would get with just the parent molecule of THC itself. And... So, and it seems to accumulate a lot more as well.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

So at any given time, you know, you've got THC kind of leaking out of the gut, going through the liver, making 11-hydroxy, and it progressively accumulates in the brain. And that's one of the reasons why it takes, you know, 45 to 90 minutes to kick in. But then the high itself also lasts like six hours, four to six, sometimes eight, depending on the person, what they've eaten.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

So at any given time, you know, you've got THC kind of leaking out of the gut, going through the liver, making 11-hydroxy, and it progressively accumulates in the brain. And that's one of the reasons why it takes, you know, 45 to 90 minutes to kick in. But then the high itself also lasts like six hours, four to six, sometimes eight, depending on the person, what they've eaten.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

So at any given time, you know, you've got THC kind of leaking out of the gut, going through the liver, making 11-hydroxy, and it progressively accumulates in the brain. And that's one of the reasons why it takes, you know, 45 to 90 minutes to kick in. But then the high itself also lasts like six hours, four to six, sometimes eight, depending on the person, what they've eaten.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Versus inhalation is just this like spike. So you get this very rapid because it goes right through the lungs into the blood, goes into the brain, but it also clears out. And so, yeah, people will start feeling intoxicated two to five minutes. The peak high is like 15 to 30 minutes maybe from consumption. And then they'll start to come back down.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Versus inhalation is just this like spike. So you get this very rapid because it goes right through the lungs into the blood, goes into the brain, but it also clears out. And so, yeah, people will start feeling intoxicated two to five minutes. The peak high is like 15 to 30 minutes maybe from consumption. And then they'll start to come back down.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Versus inhalation is just this like spike. So you get this very rapid because it goes right through the lungs into the blood, goes into the brain, but it also clears out. And so, yeah, people will start feeling intoxicated two to five minutes. The peak high is like 15 to 30 minutes maybe from consumption. And then they'll start to come back down.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And you will still see some indications of intoxication that can go on for three to four hours. But the bulk of the intoxication from inhalation is done by two hours for the most part.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And you will still see some indications of intoxication that can go on for three to four hours. But the bulk of the intoxication from inhalation is done by two hours for the most part.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And you will still see some indications of intoxication that can go on for three to four hours. But the bulk of the intoxication from inhalation is done by two hours for the most part.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

I mean, you could still fail a drug test at 80s. I would say โ€“ I feel like โ€“ I think the way it was worded more, it was like that โ€“ you made it sound like that was the standard. I wouldn't say that was the standard at all. I would say โ€“ For the majority of people, 30 days probably after that, they would not pass or they would be able to pass a drug test.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

I mean, you could still fail a drug test at 80s. I would say โ€“ I feel like โ€“ I think the way it was worded more, it was like that โ€“ you made it sound like that was the standard. I wouldn't say that was the standard at all. I would say โ€“ For the majority of people, 30 days probably after that, they would not pass or they would be able to pass a drug test.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

I mean, you could still fail a drug test at 80s. I would say โ€“ I feel like โ€“ I think the way it was worded more, it was like that โ€“ you made it sound like that was the standard. I wouldn't say that was the standard at all. I would say โ€“ For the majority of people, 30 days probably after that, they would not pass or they would be able to pass a drug test.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Yeah, after abstaining for 30 days. And it's going to be highly variable depending on how much you consume. I mean, if you're talking about someone who's used it once, I don't imagine it would be in your system that long. That'd be surprising. The thing is, THC is... a lipophilic molecule. It's fat soluble. Yeah, so it's fat soluble. It likes the store. It doesn't like the blood.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Yeah, after abstaining for 30 days. And it's going to be highly variable depending on how much you consume. I mean, if you're talking about someone who's used it once, I don't imagine it would be in your system that long. That'd be surprising. The thing is, THC is... a lipophilic molecule. It's fat soluble. Yeah, so it's fat soluble. It likes the store. It doesn't like the blood.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Yeah, after abstaining for 30 days. And it's going to be highly variable depending on how much you consume. I mean, if you're talking about someone who's used it once, I don't imagine it would be in your system that long. That'd be surprising. The thing is, THC is... a lipophilic molecule. It's fat soluble. Yeah, so it's fat soluble. It likes the store. It doesn't like the blood.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

The blood is aqueous and watery. It likes fat. So it goes into the brain, it goes into the fat, and it kind of resides there. It can essentially kind of slowly leak back. As THC concentrations in the blood would reduce, THC that's in the fat will start kind of leaking back into the blood still. So detectably, you will still have THC for quite some time.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

The blood is aqueous and watery. It likes fat. So it goes into the brain, it goes into the fat, and it kind of resides there. It can essentially kind of slowly leak back. As THC concentrations in the blood would reduce, THC that's in the fat will start kind of leaking back into the blood still. So detectably, you will still have THC for quite some time.