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Dr. Matthew Hill

๐Ÿ‘ค Speaker
1842 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

The blood is aqueous and watery. It likes fat. So it goes into the brain, it goes into the fat, and it kind of resides there. It can essentially kind of slowly leak back. As THC concentrations in the blood would reduce, THC that's in the fat will start kind of leaking back into the blood still. So detectably, you will still have THC for quite some time.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

I mean, some of this, again, it's going to be dependent on how much cannabis someone's used, how much THC they've consumed, how long it's been in their system for. I would have thought this was going to be somewhat reflective of people's body fat content, although talking to colleagues who do this, they say not always.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

I mean, some of this, again, it's going to be dependent on how much cannabis someone's used, how much THC they've consumed, how long it's been in their system for. I would have thought this was going to be somewhat reflective of people's body fat content, although talking to colleagues who do this, they say not always.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

I mean, some of this, again, it's going to be dependent on how much cannabis someone's used, how much THC they've consumed, how long it's been in their system for. I would have thought this was going to be somewhat reflective of people's body fat content, although talking to colleagues who do this, they say not always.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

But we do know certain things like exercise, for example, anything that's going to trigger adrenaline because adrenaline is lipolytic. So adrenaline causes fat to โ€“ metabolize and release stuff that's inside it. So there are plenty of cases I've heard from people where they were testing themselves and were negative and then went for a run or went to the gym and then tested positive.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

But we do know certain things like exercise, for example, anything that's going to trigger adrenaline because adrenaline is lipolytic. So adrenaline causes fat to โ€“ metabolize and release stuff that's inside it. So there are plenty of cases I've heard from people where they were testing themselves and were negative and then went for a run or went to the gym and then tested positive.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

But we do know certain things like exercise, for example, anything that's going to trigger adrenaline because adrenaline is lipolytic. So adrenaline causes fat to โ€“ metabolize and release stuff that's inside it. So there are plenty of cases I've heard from people where they were testing themselves and were negative and then went for a run or went to the gym and then tested positive.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Or lost weight. Yeah, or they've lost weight. And anything that's going to cause the lipolysis to occur so that it releases that THC, you can certainly all of a sudden test positive again when someone had tested negative previously just because of the fact that there still is some in the fat.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Or lost weight. Yeah, or they've lost weight. And anything that's going to cause the lipolysis to occur so that it releases that THC, you can certainly all of a sudden test positive again when someone had tested negative previously just because of the fact that there still is some in the fat.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Or lost weight. Yeah, or they've lost weight. And anything that's going to cause the lipolysis to occur so that it releases that THC, you can certainly all of a sudden test positive again when someone had tested negative previously just because of the fact that there still is some in the fat.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And so this is where something like โ€“ and this is what I mean by standardization of regulatory issues become very complicated. I remember โ€“ Right when legalization happened in Canada, all these kind of chemists were like talking to me about they're going to create like a breathalyzer for cannabis because this way they'll be able to do roadside detection the same way they could do with alcohol.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And so this is where something like โ€“ and this is what I mean by standardization of regulatory issues become very complicated. I remember โ€“ Right when legalization happened in Canada, all these kind of chemists were like talking to me about they're going to create like a breathalyzer for cannabis because this way they'll be able to do roadside detection the same way they could do with alcohol.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And so this is where something like โ€“ and this is what I mean by standardization of regulatory issues become very complicated. I remember โ€“ Right when legalization happened in Canada, all these kind of chemists were like talking to me about they're going to create like a breathalyzer for cannabis because this way they'll be able to do roadside detection the same way they could do with alcohol.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And I kept trying to say to them, I'm like, the rate limiting step here is not the science of detection thresholds. It's the biology of how the body processes cannabis. And you're never going to get a test that works because you can take someone who has eaten an edible and is profoundly intoxicated, and they will have possibly under five nanograms per ml of THC in their blood.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And I kept trying to say to them, I'm like, the rate limiting step here is not the science of detection thresholds. It's the biology of how the body processes cannabis. And you're never going to get a test that works because you can take someone who has eaten an edible and is profoundly intoxicated, and they will have possibly under five nanograms per ml of THC in their blood.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And I kept trying to say to them, I'm like, the rate limiting step here is not the science of detection thresholds. It's the biology of how the body processes cannabis. And you're never going to get a test that works because you can take someone who has eaten an edible and is profoundly intoxicated, and they will have possibly under five nanograms per ml of THC in their blood.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

You get a bit of it from inhalant, but not nearly as much as you get from edibles.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

You get a bit of it from inhalant, but not nearly as much as you get from edibles.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

You get a bit of it from inhalant, but not nearly as much as you get from edibles.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

It is, but it's also the timeline because of the fact that with inhalation, it's like a bolus that hits you at once. You get a high blood level. With edibles, it's like the time course. So, I mean, it's going to be like five nanograms per mil, let's say, but it would be like that for a long time. Whereas the 100 nanogram per mil from smoking is like for 20 minutes and then it starts dropping.