Dr. Matthew Hill

I know people love to leverage things. If it's a plant, it's natural and safe. And there's obviously issues we'll talk about with that. But I mean, really, this is just biological redundancy. I mean, nature only has so many ways to create something. And so there's going to be things that end up overlapping in the way that they function.

I know people love to leverage things. If it's a plant, it's natural and safe. And there's obviously issues we'll talk about with that. But I mean, really, this is just biological redundancy. I mean, nature only has so many ways to create something. And so there's going to be things that end up overlapping in the way that they function.

And so the receptor that's in the brain and throughout the body, the CB1, and there is also a CB2 receptor. It's not really expressed in the brain. It's in some of the immune cells in the brain and maybe some limited distribution in actual brain cell neurons. Where in the body is it expressing? It's mostly immune cells. So you'll see CB2s mostly on like macrophages or other kind of immune cells.

And so the receptor that's in the brain and throughout the body, the CB1, and there is also a CB2 receptor. It's not really expressed in the brain. It's in some of the immune cells in the brain and maybe some limited distribution in actual brain cell neurons. Where in the body is it expressing? It's mostly immune cells. So you'll see CB2s mostly on like macrophages or other kind of immune cells.

And so the receptor that's in the brain and throughout the body, the CB1, and there is also a CB2 receptor. It's not really expressed in the brain. It's in some of the immune cells in the brain and maybe some limited distribution in actual brain cell neurons. Where in the body is it expressing? It's mostly immune cells. So you'll see CB2s mostly on like macrophages or other kind of immune cells.

Cells that gobble up debris. Yeah. And that basically, you know, regulate inflammatory processes. And so the main role of CB2 seems to be much more about like regulating inflammation. So that's kind of a separate role that can certainly impact the brain in different ways.

Cells that gobble up debris. Yeah. And that basically, you know, regulate inflammatory processes. And so the main role of CB2 seems to be much more about like regulating inflammation. So that's kind of a separate role that can certainly impact the brain in different ways.

Cells that gobble up debris. Yeah. And that basically, you know, regulate inflammatory processes. And so the main role of CB2 seems to be much more about like regulating inflammation. So that's kind of a separate role that can certainly impact the brain in different ways.

But when we talk about the effects on the central nervous system and the brain and behavior, we're talking almost entirely about CB1. And so both the CB1 and CB2 receptors, like I said, don't exist because nature was like, humans are going to find cannabis. This will all work together now. So there are molecules our body produces, which we call endocannabinoids.

But when we talk about the effects on the central nervous system and the brain and behavior, we're talking almost entirely about CB1. And so both the CB1 and CB2 receptors, like I said, don't exist because nature was like, humans are going to find cannabis. This will all work together now. So there are molecules our body produces, which we call endocannabinoids.

But when we talk about the effects on the central nervous system and the brain and behavior, we're talking almost entirely about CB1. And so both the CB1 and CB2 receptors, like I said, don't exist because nature was like, humans are going to find cannabis. This will all work together now. So there are molecules our body produces, which we call endocannabinoids.

And they are kind of funny little molecules because they don't really behave. Like certainly in the brain, they don't behave like a normal neurotransmitter. So, I mean, I assume most people who listen to your podcast are relatively adept with the basic idea of how neurons work.

And they are kind of funny little molecules because they don't really behave. Like certainly in the brain, they don't behave like a normal neurotransmitter. So, I mean, I assume most people who listen to your podcast are relatively adept with the basic idea of how neurons work.

And they are kind of funny little molecules because they don't really behave. Like certainly in the brain, they don't behave like a normal neurotransmitter. So, I mean, I assume most people who listen to your podcast are relatively adept with the basic idea of how neurons work.

So you have neuron A, let's call it the presynaptic neuron because you have that gap between the two cells where they communicate called the synapse. So neuron A works. releases a transmitter, and it can be something that excites the neighboring cell, neuron B, or it can inhibit it.

So you have neuron A, let's call it the presynaptic neuron because you have that gap between the two cells where they communicate called the synapse. So neuron A works. releases a transmitter, and it can be something that excites the neighboring cell, neuron B, or it can inhibit it.

So you have neuron A, let's call it the presynaptic neuron because you have that gap between the two cells where they communicate called the synapse. So neuron A works. releases a transmitter, and it can be something that excites the neighboring cell, neuron B, or it can inhibit it.

And so the way that we always kind of talk about neurotransmission in the brain is neuron A releases a chemical that crosses the synapse, acts on neuron B, and it can either jack that neuron's activity up or it can scale it down. And that affects brain-wide patterns of activity.

And so the way that we always kind of talk about neurotransmission in the brain is neuron A releases a chemical that crosses the synapse, acts on neuron B, and it can either jack that neuron's activity up or it can scale it down. And that affects brain-wide patterns of activity.

And so the way that we always kind of talk about neurotransmission in the brain is neuron A releases a chemical that crosses the synapse, acts on neuron B, and it can either jack that neuron's activity up or it can scale it down. And that affects brain-wide patterns of activity.