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Dr. Matthew Hill

๐Ÿ‘ค Speaker
1842 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

I feel like there is some older work I could dig up to see if I could find that is either in like, it might even be in pigeons, but it might be in rodents that's looking at like temporal ordering and they give animals cannabinoids. And that's kind of a cleaner way of seeing because they are very good at learning. Like if I wait 10 minutes and then I engage in a behavior, I get a reward.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And so you can really train animals to have this ordinal timing where they kind of know distinct periods of time. And if they give them cannabinoids, they respond differently. So in that context, it does still seem to produce some state where there's an altered perception of time passing.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And so you can really train animals to have this ordinal timing where they kind of know distinct periods of time. And if they give them cannabinoids, they respond differently. So in that context, it does still seem to produce some state where there's an altered perception of time passing.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And so you can really train animals to have this ordinal timing where they kind of know distinct periods of time. And if they give them cannabinoids, they respond differently. So in that context, it does still seem to produce some state where there's an altered perception of time passing.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And so I think if we were going to really understand the mechanism of it, that would probably be the way to go. But I'm not super familiar with the work because no one's... I mean, anything I can think of is pretty old. I can't think of anything modern where people have actually looked at this. Interesting.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And so I think if we were going to really understand the mechanism of it, that would probably be the way to go. But I'm not super familiar with the work because no one's... I mean, anything I can think of is pretty old. I can't think of anything modern where people have actually looked at this. Interesting.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And so I think if we were going to really understand the mechanism of it, that would probably be the way to go. But I'm not super familiar with the work because no one's... I mean, anything I can think of is pretty old. I can't think of anything modern where people have actually looked at this. Interesting.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

I think we almost need to take a step back actually to talk about how cannabis works in the brain before we kind of go into that. So THC as a molecule exerts almost all its effects. They're acting at this one receptor for the most part that's widely expressed through the brain called the cannabinoid type 1 receptor. CB1. Yeah, CB1 is the shorthand for it.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

I think we almost need to take a step back actually to talk about how cannabis works in the brain before we kind of go into that. So THC as a molecule exerts almost all its effects. They're acting at this one receptor for the most part that's widely expressed through the brain called the cannabinoid type 1 receptor. CB1. Yeah, CB1 is the shorthand for it.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

I think we almost need to take a step back actually to talk about how cannabis works in the brain before we kind of go into that. So THC as a molecule exerts almost all its effects. They're acting at this one receptor for the most part that's widely expressed through the brain called the cannabinoid type 1 receptor. CB1. Yeah, CB1 is the shorthand for it.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And I think, you know, as people tend to create analogies to describe what receptors are, for those of you who don't know, most people use like a lock and key analogy that like a receptor would be a protein that sits on a cell and a molecule that binds to it like THC is the key that fits in that lock. When it activates it, it triggers some biological process in the cell, in this case a neuron.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And I think, you know, as people tend to create analogies to describe what receptors are, for those of you who don't know, most people use like a lock and key analogy that like a receptor would be a protein that sits on a cell and a molecule that binds to it like THC is the key that fits in that lock. When it activates it, it triggers some biological process in the cell, in this case a neuron.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And I think, you know, as people tend to create analogies to describe what receptors are, for those of you who don't know, most people use like a lock and key analogy that like a receptor would be a protein that sits on a cell and a molecule that binds to it like THC is the key that fits in that lock. When it activates it, it triggers some biological process in the cell, in this case a neuron.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

that changes its activity in some capacity. And so THC acts on these CB1 receptors, which are very widely expressed. In fact, outside of like kind of ion channels that are expressed in the brain, the CB1 is, I think, one of the most, if not the most widely expressed receptor in the brain. It's everywhere. So it's really important.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

that changes its activity in some capacity. And so THC acts on these CB1 receptors, which are very widely expressed. In fact, outside of like kind of ion channels that are expressed in the brain, the CB1 is, I think, one of the most, if not the most widely expressed receptor in the brain. It's everywhere. So it's really important.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

that changes its activity in some capacity. And so THC acts on these CB1 receptors, which are very widely expressed. In fact, outside of like kind of ion channels that are expressed in the brain, the CB1 is, I think, one of the most, if not the most widely expressed receptor in the brain. It's everywhere. So it's really important.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And I think as kind of you had alluded to previously, it doesn't exist in the, you know, this didn't evolve in humans in the hopes that one day humans would find cannabis.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And I think as kind of you had alluded to previously, it doesn't exist in the, you know, this didn't evolve in humans in the hopes that one day humans would find cannabis.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And I think as kind of you had alluded to previously, it doesn't exist in the, you know, this didn't evolve in humans in the hopes that one day humans would find cannabis.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

I know people love to leverage things. If it's a plant, it's natural and safe. And there's obviously issues we'll talk about with that. But I mean, really, this is just biological redundancy. I mean, nature only has so many ways to create something. And so there's going to be things that end up overlapping in the way that they function.