Dr. Matthew Hill

And yet in the wild and people who are using it on their own, we're using doses of 10 to 20 milligrams and reporting these effects. And the thing is that I think a lot of people don't also realize is CBD has absolutely horrific bioavailability.

And yet in the wild and people who are using it on their own, we're using doses of 10 to 20 milligrams and reporting these effects. And the thing is that I think a lot of people don't also realize is CBD has absolutely horrific bioavailability.

And yet in the wild and people who are using it on their own, we're using doses of 10 to 20 milligrams and reporting these effects. And the thing is that I think a lot of people don't also realize is CBD has absolutely horrific bioavailability.

Like, so if you take it orally in an oil or in a gummy or whatever you consume it in, now this might be different with some of these beverages that are out there. I don't know if anyone's actually ever done the pharmacokinetics on them. At least I've never seen it. But standard roots, we're talking 4%. like very, very little, actually leaves your gut into your bloodstream.

Like, so if you take it orally in an oil or in a gummy or whatever you consume it in, now this might be different with some of these beverages that are out there. I don't know if anyone's actually ever done the pharmacokinetics on them. At least I've never seen it. But standard roots, we're talking 4%. like very, very little, actually leaves your gut into your bloodstream.

Like, so if you take it orally in an oil or in a gummy or whatever you consume it in, now this might be different with some of these beverages that are out there. I don't know if anyone's actually ever done the pharmacokinetics on them. At least I've never seen it. But standard roots, we're talking 4%. like very, very little, actually leaves your gut into your bloodstream.

Now we do know from the studies from GW who created the pharmaceutical version of CBD that was used for a lot of the pediatric epilepsy studies that they did, I don't know if it was random or intentional, find that opposite to something like alcohol, If you had just eaten a fatty meal, that actually enhanced the bioavailability of CBD dramatically.

Now we do know from the studies from GW who created the pharmaceutical version of CBD that was used for a lot of the pediatric epilepsy studies that they did, I don't know if it was random or intentional, find that opposite to something like alcohol, If you had just eaten a fatty meal, that actually enhanced the bioavailability of CBD dramatically.

Now we do know from the studies from GW who created the pharmaceutical version of CBD that was used for a lot of the pediatric epilepsy studies that they did, I don't know if it was random or intentional, find that opposite to something like alcohol, If you had just eaten a fatty meal, that actually enhanced the bioavailability of CBD dramatically.

So then it went up to like maybe 20% got into the blood. But that's probably because, again, CBD is a fatty molecule. It likes fatty environments. And for some reason, having fat in the stomach and in the gut seems to promote its ability to get into the bloodstream. You can see it now.

So then it went up to like maybe 20% got into the blood. But that's probably because, again, CBD is a fatty molecule. It likes fatty environments. And for some reason, having fat in the stomach and in the gut seems to promote its ability to get into the bloodstream. You can see it now.

So then it went up to like maybe 20% got into the blood. But that's probably because, again, CBD is a fatty molecule. It likes fatty environments. And for some reason, having fat in the stomach and in the gut seems to promote its ability to get into the bloodstream. You can see it now.

But yeah, I mean, and so because of this, it's like you're taking very low doses of CBD that have very poor bioavailability. And then people really stand by the effects of these. And so I'm like, you know, what I would always say is if it works for you, there's no reason to stop it. because you're having benefit from it. But would I ever recommend someone do this?

But yeah, I mean, and so because of this, it's like you're taking very low doses of CBD that have very poor bioavailability. And then people really stand by the effects of these. And so I'm like, you know, what I would always say is if it works for you, there's no reason to stop it. because you're having benefit from it. But would I ever recommend someone do this?

But yeah, I mean, and so because of this, it's like you're taking very low doses of CBD that have very poor bioavailability. And then people really stand by the effects of these. And so I'm like, you know, what I would always say is if it works for you, there's no reason to stop it. because you're having benefit from it. But would I ever recommend someone do this?

No, I wouldn't, because I can't say that I think that this has any biological activity. Because even when we start looking at these potential targets of what CBD could interact with, there's a couple of receptors. People have said, you know, it might interact with serotonin receptor.

No, I wouldn't, because I can't say that I think that this has any biological activity. Because even when we start looking at these potential targets of what CBD could interact with, there's a couple of receptors. People have said, you know, it might interact with serotonin receptor.

No, I wouldn't, because I can't say that I think that this has any biological activity. Because even when we start looking at these potential targets of what CBD could interact with, there's a couple of receptors. People have said, you know, it might interact with serotonin receptor.

There's some of these like random orphan receptors that we don't know a lot of what they do that CBD might interact with. But like the concentrations you need to hit those are reasonable. And you're not getting that in the blood and certainly not in the brain of people from consuming incredibly low doses of CBD. So the whole market that exists for CBD to me is a little bizarre.

There's some of these like random orphan receptors that we don't know a lot of what they do that CBD might interact with. But like the concentrations you need to hit those are reasonable. And you're not getting that in the blood and certainly not in the brain of people from consuming incredibly low doses of CBD. So the whole market that exists for CBD to me is a little bizarre.