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Dr. Matthew Hill

πŸ‘€ Speaker
1842 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

I think that's a placebo effect. And I say that because the majority of gummies are about like two megs, five megs, 20 megs maybe.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

I think that's a placebo effect. And I say that because the majority of gummies are about like two megs, five megs, 20 megs maybe.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Yeah, yeah. I mean, THC and sleep is definitely a whole other thing. But sure, a lot of people report this with CBD. But again, so most CBD edibles or things that people take that are sold through commercial markets are in the range of 2 to 25 megs of CBD. So then I say to them, so you're aware that in the pediatric epilepsy studies, the dose ranges are like 1,500 to 2,000 makes.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Yeah, yeah. I mean, THC and sleep is definitely a whole other thing. But sure, a lot of people report this with CBD. But again, so most CBD edibles or things that people take that are sold through commercial markets are in the range of 2 to 25 megs of CBD. So then I say to them, so you're aware that in the pediatric epilepsy studies, the dose ranges are like 1,500 to 2,000 makes.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Yeah, yeah. I mean, THC and sleep is definitely a whole other thing. But sure, a lot of people report this with CBD. But again, so most CBD edibles or things that people take that are sold through commercial markets are in the range of 2 to 25 megs of CBD. So then I say to them, so you're aware that in the pediatric epilepsy studies, the dose ranges are like 1,500 to 2,000 makes.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And then you're talking about a child who weighs on the order of what, 20 kilos, maybe, you know, like 40, 60 pounds, somewhere in that range versus... So if you start dosing by weight, which is how most of these things are done, well, they'll say 20 megs per kg or whatnot.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And then you're talking about a child who weighs on the order of what, 20 kilos, maybe, you know, like 40, 60 pounds, somewhere in that range versus... So if you start dosing by weight, which is how most of these things are done, well, they'll say 20 megs per kg or whatnot.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And then you're talking about a child who weighs on the order of what, 20 kilos, maybe, you know, like 40, 60 pounds, somewhere in that range versus... So if you start dosing by weight, which is how most of these things are done, well, they'll say 20 megs per kg or whatnot.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

So someone my size, so I weigh a bit over 200 pounds, for me to take that dose of CBD at let's say 20 megs per kg at like 90-odd kilos, I mean, you're talking about me taking – A liver-damaging dose of CBD. Insane. Maybe I wouldn't say damaging. It's definitely influencing how the liver metabolizes other things because it's going to saturate those enzymes. But you're taking a very high dose.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

So someone my size, so I weigh a bit over 200 pounds, for me to take that dose of CBD at let's say 20 megs per kg at like 90-odd kilos, I mean, you're talking about me taking – A liver-damaging dose of CBD. Insane. Maybe I wouldn't say damaging. It's definitely influencing how the liver metabolizes other things because it's going to saturate those enzymes. But you're taking a very high dose.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

So someone my size, so I weigh a bit over 200 pounds, for me to take that dose of CBD at let's say 20 megs per kg at like 90-odd kilos, I mean, you're talking about me taking – A liver-damaging dose of CBD. Insane. Maybe I wouldn't say damaging. It's definitely influencing how the liver metabolizes other things because it's going to saturate those enzymes. But you're taking a very high dose.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Yeah, I can't speak to that because I actually do not know the metabolism of alcohol well enough. I don't believe so because that's alcohol dehydrogenase. So that would probably be a separate enzyme pathway than the SIPS.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Yeah, I can't speak to that because I actually do not know the metabolism of alcohol well enough. I don't believe so because that's alcohol dehydrogenase. So that would probably be a separate enzyme pathway than the SIPS.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Yeah, I can't speak to that because I actually do not know the metabolism of alcohol well enough. I don't believe so because that's alcohol dehydrogenase. So that would probably be a separate enzyme pathway than the SIPS.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Yeah, but I don't know if it would have an effect in that capacity. I mean, they've definitely seen this, like they know the list of medications that this is a problem for. So it's things like warfarin and like blood thinners. Blood thinners. And the anti-epileptics funnel into the same metabolic pathway as this THC. So there's certain things that this would influence.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Yeah, but I don't know if it would have an effect in that capacity. I mean, they've definitely seen this, like they know the list of medications that this is a problem for. So it's things like warfarin and like blood thinners. Blood thinners. And the anti-epileptics funnel into the same metabolic pathway as this THC. So there's certain things that this would influence.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Yeah, but I don't know if it would have an effect in that capacity. I mean, they've definitely seen this, like they know the list of medications that this is a problem for. So it's things like warfarin and like blood thinners. Blood thinners. And the anti-epileptics funnel into the same metabolic pathway as this THC. So there's certain things that this would influence.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

I don't know if I would say this would be in the context of alcohol, but I think more so, I mean, what I try and point out to people repeatedly is I have yet to see a blinded clinical study that has found any effect of CBD that's efficacious that's under 300 to 500 milligrams. And-

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

I don't know if I would say this would be in the context of alcohol, but I think more so, I mean, what I try and point out to people repeatedly is I have yet to see a blinded clinical study that has found any effect of CBD that's efficacious that's under 300 to 500 milligrams. And-

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

I don't know if I would say this would be in the context of alcohol, but I think more so, I mean, what I try and point out to people repeatedly is I have yet to see a blinded clinical study that has found any effect of CBD that's efficacious that's under 300 to 500 milligrams. And-