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Dr. Matthew Hill

πŸ‘€ Speaker
1842 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

CYP enzymes, like the cluster of enzymes that metabolize things, is very specific ones that CBD hits. And so as a consequence, one of them is what choose THC up. So you can get a potentiation of THC by inhibiting its metabolism if you have high enough CBD on board.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Yeah. I mean, so what you're saying is like what we said is the entourage effect. And I think that is a theory that is held by a lot of people that this exists. I mean, the reality is these terpenes and minor cannabinoids exist at such low levels that like, there's a couple of kinds of cannabis that might have like a high enough level where you're seeing something, but

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Yeah. I mean, so what you're saying is like what we said is the entourage effect. And I think that is a theory that is held by a lot of people that this exists. I mean, the reality is these terpenes and minor cannabinoids exist at such low levels that like, there's a couple of kinds of cannabis that might have like a high enough level where you're seeing something, but

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Yeah. I mean, so what you're saying is like what we said is the entourage effect. And I think that is a theory that is held by a lot of people that this exists. I mean, the reality is these terpenes and minor cannabinoids exist at such low levels that like, there's a couple of kinds of cannabis that might have like a high enough level where you're seeing something, but

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Yeah, I mean, I agree to the extent that it would be a little wild if everyone's subjective experience across different kinds of cannabis was entirely driven by some kind of expectancy, which I can't imagine is accounting for all of it. But I think when we talk about

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Yeah, I mean, I agree to the extent that it would be a little wild if everyone's subjective experience across different kinds of cannabis was entirely driven by some kind of expectancy, which I can't imagine is accounting for all of it. But I think when we talk about

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

Yeah, I mean, I agree to the extent that it would be a little wild if everyone's subjective experience across different kinds of cannabis was entirely driven by some kind of expectancy, which I can't imagine is accounting for all of it. But I think when we talk about

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

sativa versus indica i think there's a huge bias that's going into there um but one of the things with cbd that's interesting unlike thc is you can actually do pretty clean blinded studies because it's really hard to give someone thc and them not know they're on thc right this was the big problem with the mdma trial that happened recently is that people who got the placebo

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

sativa versus indica i think there's a huge bias that's going into there um but one of the things with cbd that's interesting unlike thc is you can actually do pretty clean blinded studies because it's really hard to give someone thc and them not know they're on thc right this was the big problem with the mdma trial that happened recently is that people who got the placebo

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

sativa versus indica i think there's a huge bias that's going into there um but one of the things with cbd that's interesting unlike thc is you can actually do pretty clean blinded studies because it's really hard to give someone thc and them not know they're on thc right this was the big problem with the mdma trial that happened recently is that people who got the placebo

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

It's very challenging to give someone a psychoactive drug and a placebo and them not know which one they have. Whereas because CBD doesn't produce an intoxicating state and it's not really perceptible from the person who's taken it that it's doing anything, that actually does make it far more amenable to do blinded trials with. And so...

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

It's very challenging to give someone a psychoactive drug and a placebo and them not know which one they have. Whereas because CBD doesn't produce an intoxicating state and it's not really perceptible from the person who's taken it that it's doing anything, that actually does make it far more amenable to do blinded trials with. And so...

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

It's very challenging to give someone a psychoactive drug and a placebo and them not know which one they have. Whereas because CBD doesn't produce an intoxicating state and it's not really perceptible from the person who's taken it that it's doing anything, that actually does make it far more amenable to do blinded trials with. And so...

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

I mean, the interesting thing with CBD, and this is where I get a lot of people that get angry at me as well, is that I would argue that the overwhelming majority of the effects of CBD that people report are all placebo effects. And I say that because people leverage the epilepsy stuff and some of the clinical work and say, but we know it does things.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

I mean, the interesting thing with CBD, and this is where I get a lot of people that get angry at me as well, is that I would argue that the overwhelming majority of the effects of CBD that people report are all placebo effects. And I say that because people leverage the epilepsy stuff and some of the clinical work and say, but we know it does things.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

I mean, the interesting thing with CBD, and this is where I get a lot of people that get angry at me as well, is that I would argue that the overwhelming majority of the effects of CBD that people report are all placebo effects. And I say that because people leverage the epilepsy stuff and some of the clinical work and say, but we know it does things.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And my response to them is, do you know what dose those people are getting? Because this is something that for some reason has not made the transition from science into pop culture. Right.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And my response to them is, do you know what dose those people are getting? Because this is something that for some reason has not made the transition from science into pop culture. Right.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

And my response to them is, do you know what dose those people are getting? Because this is something that for some reason has not made the transition from science into pop culture. Right.

Huberman Lab
Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

I think that's a placebo effect. And I say that because the majority of gummies are about like two megs, five megs, 20 megs maybe.