Dr. Matthew Hill

Yeah.

Yeah.

Yeah.

That's kind of how I describe to people if they ever ask me for what the pharmacology of CBD is. I'm like, that's not the only mechanism. But the thing that was important in CC studies that I think is relevant is that it was not super high concentrations of CBD that caused that. So you could get this adenosine accumulation at...

That's kind of how I describe to people if they ever ask me for what the pharmacology of CBD is. I'm like, that's not the only mechanism. But the thing that was important in CC studies that I think is relevant is that it was not super high concentrations of CBD that caused that. So you could get this adenosine accumulation at...

That's kind of how I describe to people if they ever ask me for what the pharmacology of CBD is. I'm like, that's not the only mechanism. But the thing that was important in CC studies that I think is relevant is that it was not super high concentrations of CBD that caused that. So you could get this adenosine accumulation at...

you're not talking like micromolar levels of CBD, which is what a lot of studies have done. And so even when we're talking about the allosteric modulatory site, like yes, there's evidence for it. And it is convincing evidence. It's just the dose range in there. You're kind of like, who's getting hit with CBD at that level where you're getting these effects and more so,

you're not talking like micromolar levels of CBD, which is what a lot of studies have done. And so even when we're talking about the allosteric modulatory site, like yes, there's evidence for it. And it is convincing evidence. It's just the dose range in there. You're kind of like, who's getting hit with CBD at that level where you're getting these effects and more so,

you're not talking like micromolar levels of CBD, which is what a lot of studies have done. And so even when we're talking about the allosteric modulatory site, like yes, there's evidence for it. And it is convincing evidence. It's just the dose range in there. You're kind of like, who's getting hit with CBD at that level where you're getting these effects and more so,

when they've done the blinded work, like when Ryan Vandery at Hopkins again, who is one of the main people who's done a lot of this work, has actually blindly given people CBD dosing with THC, finds the opposite, that it actually amplifies some of the effects of THC.

when they've done the blinded work, like when Ryan Vandery at Hopkins again, who is one of the main people who's done a lot of this work, has actually blindly given people CBD dosing with THC, finds the opposite, that it actually amplifies some of the effects of THC.

when they've done the blinded work, like when Ryan Vandery at Hopkins again, who is one of the main people who's done a lot of this work, has actually blindly given people CBD dosing with THC, finds the opposite, that it actually amplifies some of the effects of THC.

And this was something we learned from the pediatric epilepsy world was that when you start giving CBD at relatively high doses, one of the things it does is saturate a lot of liver enzymes. And so some of the efficacy in the pediatric epilepsy space may be a secondary effect due to an accumulation of some of the anti-epileptics as well because they're not being metabolized the same way.

And this was something we learned from the pediatric epilepsy world was that when you start giving CBD at relatively high doses, one of the things it does is saturate a lot of liver enzymes. And so some of the efficacy in the pediatric epilepsy space may be a secondary effect due to an accumulation of some of the anti-epileptics as well because they're not being metabolized the same way.

And this was something we learned from the pediatric epilepsy world was that when you start giving CBD at relatively high doses, one of the things it does is saturate a lot of liver enzymes. And so some of the efficacy in the pediatric epilepsy space may be a secondary effect due to an accumulation of some of the anti-epileptics as well because they're not being metabolized the same way.

And this has now been very well replicated. We know that once you start taking CBD, when they hit doses that are at the clinical level, you're going to start having hepatic effects. So it's going to affect the liver, and it's going to affect the ability of the liver to chew up other drugs. And there's very specific –

And this has now been very well replicated. We know that once you start taking CBD, when they hit doses that are at the clinical level, you're going to start having hepatic effects. So it's going to affect the liver, and it's going to affect the ability of the liver to chew up other drugs. And there's very specific –

And this has now been very well replicated. We know that once you start taking CBD, when they hit doses that are at the clinical level, you're going to start having hepatic effects. So it's going to affect the liver, and it's going to affect the ability of the liver to chew up other drugs. And there's very specific –

CYP enzymes, like the cluster of enzymes that metabolize things, is very specific ones that CBD hits. And so as a consequence, one of them is what choose THC up. So you can get a potentiation of THC by inhibiting its metabolism if you have high enough CBD on board.

CYP enzymes, like the cluster of enzymes that metabolize things, is very specific ones that CBD hits. And so as a consequence, one of them is what choose THC up. So you can get a potentiation of THC by inhibiting its metabolism if you have high enough CBD on board.