Dr. Matthew Hill

Like you can certainly, I mean, you can have products that are made that are like oil-based products, at least, that have a certain amount of CBD and a certain amount of THC. And people do go for those. And there's this – I mean one of the arguments people make is they say, oh, introducing CBD reduces the adverse effects of THC.

Like you can certainly, I mean, you can have products that are made that are like oil-based products, at least, that have a certain amount of CBD and a certain amount of THC. And people do go for those. And there's this – I mean one of the arguments people make is they say, oh, introducing CBD reduces the adverse effects of THC.

I'm like, well, if you're using it in a strain, that's simply because the strain of cannabis has less THC now. So it's impossible to separate. So you've bred it out. But I mean like a lot of this was based on some work that came out a long time ago from Brazil where they showed that like giving CBD with a relatively high dose of THC could curb some anxiety that came out from high-dose THC.

I'm like, well, if you're using it in a strain, that's simply because the strain of cannabis has less THC now. So it's impossible to separate. So you've bred it out. But I mean like a lot of this was based on some work that came out a long time ago from Brazil where they showed that like giving CBD with a relatively high dose of THC could curb some anxiety that came out from high-dose THC.

I'm like, well, if you're using it in a strain, that's simply because the strain of cannabis has less THC now. So it's impossible to separate. So you've bred it out. But I mean like a lot of this was based on some work that came out a long time ago from Brazil where they showed that like giving CBD with a relatively high dose of THC could curb some anxiety that came out from high-dose THC.

There is some evidence to support that, that we would call these allosteric modulators. There's some evidence to suggest that CBD may interact with an allosteric site on the cannabinoid receptor that makes THC bind less.

There is some evidence to support that, that we would call these allosteric modulators. There's some evidence to suggest that CBD may interact with an allosteric site on the cannabinoid receptor that makes THC bind less.

There is some evidence to support that, that we would call these allosteric modulators. There's some evidence to suggest that CBD may interact with an allosteric site on the cannabinoid receptor that makes THC bind less.

It's definitely more complex than that.

It's definitely more complex than that.

It's definitely more complex than that.

So the most convincing thing that I've seen that CBD binds to is the work that C.C. Hillard has done looking at its ability to essentially block adenosine uptake. And so it can inhibit the adenosine transporter.

So the most convincing thing that I've seen that CBD binds to is the work that C.C. Hillard has done looking at its ability to essentially block adenosine uptake. And so it can inhibit the adenosine transporter.

So the most convincing thing that I've seen that CBD binds to is the work that C.C. Hillard has done looking at its ability to essentially block adenosine uptake. And so it can inhibit the adenosine transporter.

No, because you're getting more adenosine. So you get an accumulation. It blocks the adenosine transport mechanism.

No, because you're getting more adenosine. So you get an accumulation. It blocks the adenosine transport mechanism.

No, because you're getting more adenosine. So you get an accumulation. It blocks the adenosine transport mechanism.

So you get an accumulation of adenosine, which is more sedative. And that, I mean, in the PNAS paper that CC's lab had from 2006, they showed that that also mediated. It was the adenosine, I think, 2A receptor that drove the anti-inflammatory effects of CBD. So it was a secondary effect by- Sort of the opposite of-

So you get an accumulation of adenosine, which is more sedative. And that, I mean, in the PNAS paper that CC's lab had from 2006, they showed that that also mediated. It was the adenosine, I think, 2A receptor that drove the anti-inflammatory effects of CBD. So it was a secondary effect by- Sort of the opposite of-

So you get an accumulation of adenosine, which is more sedative. And that, I mean, in the PNAS paper that CC's lab had from 2006, they showed that that also mediated. It was the adenosine, I think, 2A receptor that drove the anti-inflammatory effects of CBD. So it was a secondary effect by- Sort of the opposite of-