Dr. Matthew Hill

is hugely beneficial for them. And so the Canadian military did an open label trial on this, again, not blinded. It was small numbers, but they basically found as soon as they put people on nabilone, this synthetic version of THC, it very, in like a large proportion, I think like 85% of them almost stopped having these nightmares.

And this was like a treatment resistant population that was pretty severe. So this was a big benefit. So they then took open label and did what you should and moved forward to do a double-blind placebo-controlled. Now, it was a very small sampled studies. And that is obviously always a problem with human work is if this was like 15 or 17 people.

And this was like a treatment resistant population that was pretty severe. So this was a big benefit. So they then took open label and did what you should and moved forward to do a double-blind placebo-controlled. Now, it was a very small sampled studies. And that is obviously always a problem with human work is if this was like 15 or 17 people.

And this was like a treatment resistant population that was pretty severe. So this was a big benefit. So they then took open label and did what you should and moved forward to do a double-blind placebo-controlled. Now, it was a very small sampled studies. And that is obviously always a problem with human work is if this was like 15 or 17 people.

So not powered enough to really make any kind of firm conclusions, but interesting in the sense that at least it was done in a proper crossover design where they got placebo at one point, they got Nablon at one point, it was switched, they didn't know which one they were on. Um, because they're taking it right before bed, maybe that will remove some of the subjective bias.

So not powered enough to really make any kind of firm conclusions, but interesting in the sense that at least it was done in a proper crossover design where they got placebo at one point, they got Nablon at one point, it was switched, they didn't know which one they were on. Um, because they're taking it right before bed, maybe that will remove some of the subjective bias.

So not powered enough to really make any kind of firm conclusions, but interesting in the sense that at least it was done in a proper crossover design where they got placebo at one point, they got Nablon at one point, it was switched, they didn't know which one they were on. Um, because they're taking it right before bed, maybe that will remove some of the subjective bias.

Again, you can't totally remove it, but like if someone's taking it within, you know, an hour or so of going to sleep, they may not feel behind the same way. But, uh, even under the double-blinded conditions, they found a very effective suppression of the, of the nightmares and the re-experiencing.

Again, you can't totally remove it, but like if someone's taking it within, you know, an hour or so of going to sleep, they may not feel behind the same way. But, uh, even under the double-blinded conditions, they found a very effective suppression of the, of the nightmares and the re-experiencing.

Again, you can't totally remove it, but like if someone's taking it within, you know, an hour or so of going to sleep, they may not feel behind the same way. But, uh, even under the double-blinded conditions, they found a very effective suppression of the, of the nightmares and the re-experiencing.

And then they also, at the same time, found this increase in kind of quality of life measures, which tracked with the fact that they were probably sleeping better. Um, I don't think they actually reported any change or even looked at maybe the overall PTSD score. They only reported or really focused on the nightmare component of it because that was the primary outcome of the study.

And then they also, at the same time, found this increase in kind of quality of life measures, which tracked with the fact that they were probably sleeping better. Um, I don't think they actually reported any change or even looked at maybe the overall PTSD score. They only reported or really focused on the nightmare component of it because that was the primary outcome of the study.

And then they also, at the same time, found this increase in kind of quality of life measures, which tracked with the fact that they were probably sleeping better. Um, I don't think they actually reported any change or even looked at maybe the overall PTSD score. They only reported or really focused on the nightmare component of it because that was the primary outcome of the study.

So I thought that was interesting because that's – if you look at the anecdotal data in PTSD, that's where a lot of it is focused on is using it as kind of – I wouldn't – maybe call it a sleep aid because it's really more of a modulator of the dream state.

So I thought that was interesting because that's – if you look at the anecdotal data in PTSD, that's where a lot of it is focused on is using it as kind of – I wouldn't – maybe call it a sleep aid because it's really more of a modulator of the dream state.

So I thought that was interesting because that's – if you look at the anecdotal data in PTSD, that's where a lot of it is focused on is using it as kind of – I wouldn't – maybe call it a sleep aid because it's really more of a modulator of the dream state.

I mean, depression and PTSD are both two disorders that are characterized by changes in REM. Like they have earlier onset to REM, so they go into REM faster. They tend to have some altered architecture of the REM component of their sleep. So in those states, maybe suppressing REM isn't actually a bad thing.

I mean, depression and PTSD are both two disorders that are characterized by changes in REM. Like they have earlier onset to REM, so they go into REM faster. They tend to have some altered architecture of the REM component of their sleep. So in those states, maybe suppressing REM isn't actually a bad thing.

I mean, depression and PTSD are both two disorders that are characterized by changes in REM. Like they have earlier onset to REM, so they go into REM faster. They tend to have some altered architecture of the REM component of their sleep. So in those states, maybe suppressing REM isn't actually a bad thing.

At least certainly for PTSD, I would imagine in terms of the context of the nightmares, that's providing some benefit. Whether or not it globally is changing the disease severity or improving the disease, I don't think we really have any evidence to say. But again, I can understand the...