Dr. Michael Kilgard
👤 SpeakerAppearances Over Time
Podcast Appearances
Will this really work when no one knows?
None of the investigators get to see the data.
No one gets to look at anything.
When you run a phase three pivotal trial, it's no joke.
And we usually fail.
And that's sad for us because we want it to work.
But it's the truth.
And we just accept it.
Sometimes we go back through and say, maybe it worked for a subset.
And we're still doing that.
Maybe some people did get a benefit.
But if that's true, that means some subset might have gotten worse.
Good.
Let's select these people.
So I think there's a lot of failed trials we can go back to and try to figure out.
Maybe we didn't pick the right people.
Drug companies hope that the market is as large as possible.
But what we find in our animal studies is there's a narrow range.
You've done some beautiful experiments looking at how to get retinal ganglion cells to regrow.
And the conditions need to be just right, not too much crush, not too little crush.