Dr. Michael Ormsbee

You gave everything. Every single thing we gave them. Now, obviously, it's human, so you don't know what they're sneaking in or not.

You gave everything. Every single thing we gave them. Now, obviously, it's human, so you don't know what they're sneaking in or not.

We tried to control it. And of course— then you get comments like, oh, that was too controlled. It's not real life. But we tried to control all these things.

We tried to control it. And of course— then you get comments like, oh, that was too controlled. It's not real life. But we tried to control all these things.

We're trying to answer it. So we damaged them so much that their markers just dropped off, right? As you would expect, like nobody could produce a contraction that was anything. And then it just never recovered. 72 hours later, we were nowhere near back. And in almost every other study we had looked at, you were at least close by 72 hours later. And we just never got there.

We're trying to answer it. So we damaged them so much that their markers just dropped off, right? As you would expect, like nobody could produce a contraction that was anything. And then it just never recovered. 72 hours later, we were nowhere near back. And in almost every other study we had looked at, you were at least close by 72 hours later. And we just never got there.

And so what we found, again, the type of protein didn't matter in that case. Everybody was too darn sore to actually get back to normal in this particular design. And so we just had to conclude again, like, it didn't – we had no difference in protein type. So that was getting at your protein type question was – plant-based didn't seem to matter versus whey.

And so what we found, again, the type of protein didn't matter in that case. Everybody was too darn sore to actually get back to normal in this particular design. And so we just had to conclude again, like, it didn't – we had no difference in protein type. So that was getting at your protein type question was – plant-based didn't seem to matter versus whey.

Plant protein specifically is also very important. I love this question because we – I'll give you two stories here. The first one is the story of our cottage cheese study. Okay. So we were always wondering these whole foods things. And at the time, it was still thought that casein would be the best way to go because of its slow-digesting kinetics and everything that we see during the day.

Plant protein specifically is also very important. I love this question because we – I'll give you two stories here. The first one is the story of our cottage cheese study. Okay. So we were always wondering these whole foods things. And at the time, it was still thought that casein would be the best way to go because of its slow-digesting kinetics and everything that we see during the day.

Yes. And so Luke and I have conversations about that because we think it might be different when you're sleeping. Because you're laying supine and it's subtle changes in pH to your stomach and these different things that are occurring. And we just kind of had a hunch on it. And I'll give you the answer because I actually ran this study recently. But the cottage cheese study was great.

Yes. And so Luke and I have conversations about that because we think it might be different when you're sleeping. Because you're laying supine and it's subtle changes in pH to your stomach and these different things that are occurring. And we just kind of had a hunch on it. And I'll give you the answer because I actually ran this study recently. But the cottage cheese study was great.

Went to the supermarket, pulled off a tub of it. And then I sent one to a manufacturer to exactly replicate it in a powder form. The macro, all the profile. And so then I had a semi-solid cottage cheese and a liquid to compare it to and a placebo. Wow. And so that was a neat size. We get at like the consistency of the food and what is that doing with these outcomes?

Went to the supermarket, pulled off a tub of it. And then I sent one to a manufacturer to exactly replicate it in a powder form. The macro, all the profile. And so then I had a semi-solid cottage cheese and a liquid to compare it to and a placebo. Wow. And so that was a neat size. We get at like the consistency of the food and what is that doing with these outcomes?

And what we saw in that one was, again, no difference. The cottage cheese was not different from the profile when you made it into a shake. And so those two were not different from each other, all different from placebo. Well, not all. In some of the outcomes, they were better. And sleep, we did measure in this one. We put on some watches to measure sleep in this one.

And what we saw in that one was, again, no difference. The cottage cheese was not different from the profile when you made it into a shake. And so those two were not different from each other, all different from placebo. Well, not all. In some of the outcomes, they were better. And sleep, we did measure in this one. We put on some watches to measure sleep in this one.

Again, we saw no differences in sleep. And so real basic design, looking at if we have a semi-solid or a liquid, and there were no differences there. So it turned out casein maybe isn't the only one or the best one. And so... Luke Van Loon, Jorn Chomelin, and colleagues put together a nice study looking directly at casein versus whey. And they looked at mitochondrial MPS and myofibril MPS.

Again, we saw no differences in sleep. And so real basic design, looking at if we have a semi-solid or a liquid, and there were no differences there. So it turned out casein maybe isn't the only one or the best one. And so... Luke Van Loon, Jorn Chomelin, and colleagues put together a nice study looking directly at casein versus whey. And they looked at mitochondrial MPS and myofibril MPS.

And there were no differences in pre-sleep feeding with taking either the whey or the casein.

And there were no differences in pre-sleep feeding with taking either the whey or the casein.