Dr. Michael Ormsbee

the shape before bed when we measured it the next mornings. And that's not a good thing. You don't want that to be. So we decided to introduce exercise minimally. I think it was two days a week we put in and we just did it for four weeks. But when we did even just a little bit of exercise with people who didn't usually do it, All of those negative things went away entirely.

the shape before bed when we measured it the next mornings. And that's not a good thing. You don't want that to be. So we decided to introduce exercise minimally. I think it was two days a week we put in and we just did it for four weeks. But when we did even just a little bit of exercise with people who didn't usually do it, All of those negative things went away entirely.

It just shows you how powerful exercise driving all of this stuff over the nutrition. I mean, any day that exercise base is going to be the main mover of the physiological needle. And the nutrition really just helps push it one way or the other.

It just shows you how powerful exercise driving all of this stuff over the nutrition. I mean, any day that exercise base is going to be the main mover of the physiological needle. And the nutrition really just helps push it one way or the other.

The other thing we didn't do well was that if you're sleeping at home or sleeping in the lab, how do I know how, if that's like your usual way of sleeping and does that influence fat metabolism? So I remember a reviewer said, did you measure sleep? I'm like, never even crossed my mind. And I'm doing sleep – I'm doing pre-sleep studies. So at that time, we just implemented like a survey.

The other thing we didn't do well was that if you're sleeping at home or sleeping in the lab, how do I know how, if that's like your usual way of sleeping and does that influence fat metabolism? So I remember a reviewer said, did you measure sleep? I'm like, never even crossed my mind. And I'm doing sleep – I'm doing pre-sleep studies. So at that time, we just implemented like a survey.

So you come in and we say, OK, how much did you sleep last night? Was it good or bad or usual? And then in that simple measure, we saw no differences whatsoever. And then we brought them into the laboratory and like, oh, well, surely that's not going to be great for sleep. It's a different environment and all these things.

So you come in and we say, OK, how much did you sleep last night? Was it good or bad or usual? And then in that simple measure, we saw no differences whatsoever. And then we brought them into the laboratory and like, oh, well, surely that's not going to be great for sleep. It's a different environment and all these things.

And we made it again, pen and paper, no difference in what we're finding in terms of just asking them that question. And so then we now I'll fast forward to kind of what we're getting to in a few minutes. But now we're purposefully designing for an outcome of sleep. where we've never done that before. We've always measured it for recovery.

And we made it again, pen and paper, no difference in what we're finding in terms of just asking them that question. And so then we now I'll fast forward to kind of what we're getting to in a few minutes. But now we're purposefully designing for an outcome of sleep. where we've never done that before. We've always measured it for recovery.

We've measured it for metabolism, not for the outcome of sleep as our primary aim. But we'll talk about that in a second. One of the things that I think really helps us now is that we introduced in some of our studies a technique called microdialysis.

We've measured it for metabolism, not for the outcome of sleep as our primary aim. But we'll talk about that in a second. One of the things that I think really helps us now is that we introduced in some of our studies a technique called microdialysis.

Now, that's something that I learned in grad school from a guy named Professor Bob Hickner, great friend, excellent researcher, my mentor, just a phenomenal human.

Now, that's something that I learned in grad school from a guy named Professor Bob Hickner, great friend, excellent researcher, my mentor, just a phenomenal human.

Yeah, consistently just excellent work.

Yeah, consistently just excellent work.

I did. Yeah. That's a whole other story. But it's fantastic because I have like the godfather of microdialysis in our backyard. And it's great. And that's a technique I learned in my PhD program as well. So we started implementing this microdialysis.

I did. Yeah. That's a whole other story. But it's fantastic because I have like the godfather of microdialysis in our backyard. And it's great. And that's a technique I learned in my PhD program as well. So we started implementing this microdialysis.

Yeah, it is. But yeah, I guess it's a little complicated. So imagine like getting your belly pierced. So when we originally started this, it was you pinch a roll of fat in your subcutaneous fat on your belly. And then you'd put a small needle through and then pull it out the other side and it's threaded with – A tiny probe, a flexible membrane that you can slide underneath the skin.

Yeah, it is. But yeah, I guess it's a little complicated. So imagine like getting your belly pierced. So when we originally started this, it was you pinch a roll of fat in your subcutaneous fat on your belly. And then you'd put a small needle through and then pull it out the other side and it's threaded with – A tiny probe, a flexible membrane that you can slide underneath the skin.