Dr. Michael Snyder

makes you more susceptible, let's put it that way.

I think so.

Yeah, I mean, there are cases.

It can't be that simple.

That's correct.

A good example would be Huntington's, right, where you have an expansion of a specific genetic locus.

There are elements that shift there.

And that's highly associated with Huntington's.

Those would be single condition things that trigger it.

And that does happen, but that's not most disease.

That's more the exception than the rule.

And by the way, even in those cases, there are people that escape it.

Yeah, who have somehow escaped that.

Not always understood, although they may hold clues to perhaps how others could be helped.

Right.

Well, first of all, I'm not an ALS expert.

This is where my genetics came in.

We came up with new ways of analyzing genomes.

And we applied it to ALS for reasons we thought might work.

Here I just had an amazing postdoc, Sai Zong, and a great collaborator, Jonathan Cooper-Knock, who basically sort of said, Mike, this is a great problem to apply these new methods we had for analyzing genomes.