Dr. Mink Chawla

This is very uncool. But you take all the blood out of someone's body and you pour it on a kitchen table that's at about a 5% incline.

And you allow all that blood to roll across that surface. You collect it. put it back into the patient's body. That is conceptually what this procedure is. Now, the surface of this filter is made up of a very special surface. And that surface looks like a wheat field during harvest time. All these little projections sticking up.

And you allow all that blood to roll across that surface. You collect it. put it back into the patient's body. That is conceptually what this procedure is. Now, the surface of this filter is made up of a very special surface. And that surface looks like a wheat field during harvest time. All these little projections sticking up.

And you allow all that blood to roll across that surface. You collect it. put it back into the patient's body. That is conceptually what this procedure is. Now, the surface of this filter is made up of a very special surface. And that surface looks like a wheat field during harvest time. All these little projections sticking up.

Exactly. So this is identical to the inner lining of our blood vessels, the endothelial glycocalyx. And so it's very biocompatible because- This is what the blood just came from. It came from an endothelial glycocalyx area, and now it's seeing a glycocalyx, so it doesn't get upset. So this surface is very biocompatible.

Exactly. So this is identical to the inner lining of our blood vessels, the endothelial glycocalyx. And so it's very biocompatible because- This is what the blood just came from. It came from an endothelial glycocalyx area, and now it's seeing a glycocalyx, so it doesn't get upset. So this surface is very biocompatible.

Exactly. So this is identical to the inner lining of our blood vessels, the endothelial glycocalyx. And so it's very biocompatible because- This is what the blood just came from. It came from an endothelial glycocalyx area, and now it's seeing a glycocalyx, so it doesn't get upset. So this surface is very biocompatible.

Now, the initial insight was that Staph aureus, a very nasty bug that's on all of us, was attracted to this surface. This surface is made up of heparin. So for the medically literate folks, this is the same heparin that you use to treat someone with a blood clot, but it's not being used in the same way. It's on the surface. So heparin-coated devices, the heparin is laid down like latex.

Now, the initial insight was that Staph aureus, a very nasty bug that's on all of us, was attracted to this surface. This surface is made up of heparin. So for the medically literate folks, this is the same heparin that you use to treat someone with a blood clot, but it's not being used in the same way. It's on the surface. So heparin-coated devices, the heparin is laid down like latex.

Now, the initial insight was that Staph aureus, a very nasty bug that's on all of us, was attracted to this surface. This surface is made up of heparin. So for the medically literate folks, this is the same heparin that you use to treat someone with a blood clot, but it's not being used in the same way. It's on the surface. So heparin-coated devices, the heparin is laid down like latex.

In this surface, the heparin is projected up, so it looks just like our glycocalyx.

In this surface, the heparin is projected up, so it looks just like our glycocalyx.

In this surface, the heparin is projected up, so it looks just like our glycocalyx.

So our glycol calyx is made of heparan sulfate, H-E-P-E-R-A-N. This is H-E-P-E-R-I-N, but structurally they're identical.

So our glycol calyx is made of heparan sulfate, H-E-P-E-R-A-N. This is H-E-P-E-R-I-N, but structurally they're identical.

So our glycol calyx is made of heparan sulfate, H-E-P-E-R-A-N. This is H-E-P-E-R-I-N, but structurally they're identical.

So the initial DARPA program was, hey, it tends to attract... Bugs, pathogens. So let's use it. What we've come to understand is why so many pathogens attach to this. So it started with staph and gram-negative bugs like Klebsiella and Pseudomonas, and then COVID hit. And this device binds the COVID virus.

So the initial DARPA program was, hey, it tends to attract... Bugs, pathogens. So let's use it. What we've come to understand is why so many pathogens attach to this. So it started with staph and gram-negative bugs like Klebsiella and Pseudomonas, and then COVID hit. And this device binds the COVID virus.

So the initial DARPA program was, hey, it tends to attract... Bugs, pathogens. So let's use it. What we've come to understand is why so many pathogens attach to this. So it started with staph and gram-negative bugs like Klebsiella and Pseudomonas, and then COVID hit. And this device binds the COVID virus.

It's very impressive. It's very amazing. But importantly, spike protein has heparin-binding sites. Long COVID. And it binds amyloid, which is also linked to long COVID. And it binds circulating tumor cells. Wow. And so most people then say, okay, wait a minute. Like, how can it do all this? Why is it doing this? Sounds too good to be true almost. It sounds too good to be true.