Dr. Nathan Bryan

Deficiency. So if you don't correct the ED, then what you start to see is an increase in blood pressure. And when you think about this mechanistically, so we have a finite volume of blood that's pumping throughout our body every day, every second. And if you can make nitric oxide, the blood vessels are more dilated. So now we're pumping that volume through more dilated blood vessels.

Deficiency. So if you don't correct the ED, then what you start to see is an increase in blood pressure. And when you think about this mechanistically, so we have a finite volume of blood that's pumping throughout our body every day, every second. And if you can make nitric oxide, the blood vessels are more dilated. So now we're pumping that volume through more dilated blood vessels.

But if we lose the ability to produce nitric oxide, now you don't get the dilation. Now you have smaller blood vessels. You're pumping that same volume of blood through smaller pipes, and simple physics tells us that blood pressure goes up.

But if we lose the ability to produce nitric oxide, now you don't get the dilation. Now you have smaller blood vessels. You're pumping that same volume of blood through smaller pipes, and simple physics tells us that blood pressure goes up.

Well, you're going to have high blood pressure or hypertension. And at least in the U.S., and I think these statistics probably are worldwide, but two out of three Americans have an unsafe elevation in blood pressure. And 50% of the people that are given prescription medications to treat their blood pressure do not respond with better blood pressure.

Well, you're going to have high blood pressure or hypertension. And at least in the U.S., and I think these statistics probably are worldwide, but two out of three Americans have an unsafe elevation in blood pressure. And 50% of the people that are given prescription medications to treat their blood pressure do not respond with better blood pressure.

It's because most of the drugs out there, whether they're ACE inhibitors, what's called angiotensin receptor blockers, calcium channel antagonists, the main classes of drugs that treat high blood pressure aren't targeted toward restoration of nitric oxide. So that's why we call that resistant hypertension. They're resistant to traditional therapies.

It's because most of the drugs out there, whether they're ACE inhibitors, what's called angiotensin receptor blockers, calcium channel antagonists, the main classes of drugs that treat high blood pressure aren't targeted toward restoration of nitric oxide. So that's why we call that resistant hypertension. They're resistant to traditional therapies.

And the reason they're resistant is because it's a nitric oxide problem. And those drugs aren't designed to affect nitric oxide production or improve it.

And the reason they're resistant is because it's a nitric oxide problem. And those drugs aren't designed to affect nitric oxide production or improve it.

You know, for me, I was a student at LSU School of Medicine. This was the late 90s, maybe early 2000s. But a Nobel Prize had just been awarded for the discovery of nitric oxide. There were three U.S. scientists that were awarded the Nobel Prize in Physiology and Medicine in 1998. And I was very fortunate at the time. I was a young student, probably a first-year student.

You know, for me, I was a student at LSU School of Medicine. This was the late 90s, maybe early 2000s. But a Nobel Prize had just been awarded for the discovery of nitric oxide. There were three U.S. scientists that were awarded the Nobel Prize in Physiology and Medicine in 1998. And I was very fortunate at the time. I was a young student, probably a first-year student.

And Lou Ignaro, who had just won the Nobel Prize for the discovery of nitric oxide, came and spoke and gave a lecture before the student body. And I had a chance to have a conversation with him afterwards, and I was fortunate to be invited to have dinner with him that night. And he made a very poignant statement to me.

And Lou Ignaro, who had just won the Nobel Prize for the discovery of nitric oxide, came and spoke and gave a lecture before the student body. And I had a chance to have a conversation with him afterwards, and I was fortunate to be invited to have dinner with him that night. And he made a very poignant statement to me.

He goes, if the scientific community can figure out how to restore the production of nitric oxide, it'll change the world. And it'll change the landscape of medicine. Because even then, what is that, 25, 26 years ago, that it was recognized that a loss of nitric oxide production is leading to the onset and development of many poorly managed age-related chronic diseases.

He goes, if the scientific community can figure out how to restore the production of nitric oxide, it'll change the world. And it'll change the landscape of medicine. Because even then, what is that, 25, 26 years ago, that it was recognized that a loss of nitric oxide production is leading to the onset and development of many poorly managed age-related chronic diseases.

So I go, that's a very profound statement from a guy who just won the Nobel Prize. But that was the first kind of eureka moment for me that stimulated the interest. But then my dad, and I talk about it in the book, his dad is 76 years old. In 1984, he had a car accident that left him paralyzed from the mid-back down.

So I go, that's a very profound statement from a guy who just won the Nobel Prize. But that was the first kind of eureka moment for me that stimulated the interest. But then my dad, and I talk about it in the book, his dad is 76 years old. In 1984, he had a car accident that left him paralyzed from the mid-back down.

So the majority of my life, even as a kid, I was treating dad's wounds, the cubitus ulcers, pressure ulcers on his feet, on his butt. And he developed these non-healing wounds. He was diabetic, he was paraplegic, poor blood flow, hypertension, and he developed a non-healing wound, and no wound care doc that I took him to could heal this wound.

So the majority of my life, even as a kid, I was treating dad's wounds, the cubitus ulcers, pressure ulcers on his feet, on his butt. And he developed these non-healing wounds. He was diabetic, he was paraplegic, poor blood flow, hypertension, and he developed a non-healing wound, and no wound care doc that I took him to could heal this wound.