Dr. Nathan Bryan
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Podcast Appearances
Nitric oxide affects many different things. It turns genes on. I was here this week at a nitric oxide scientific meeting. The top probably 140 scientists in the world come together every two years and we discuss the latest in nitric oxide chemistry, biology, and the clinical applications of that.
But we're learning that nitric oxide can turn genes on and turn genes off by histone modification, by affecting DNA methylation. So it's really controlling the epigenetic regulation of gene expression. So there's many things that affect that. But here's what we know in terms of fat deposition. So it's the quality of the calories that we consume, and it's how we burn calories.
But we're learning that nitric oxide can turn genes on and turn genes off by histone modification, by affecting DNA methylation. So it's really controlling the epigenetic regulation of gene expression. So there's many things that affect that. But here's what we know in terms of fat deposition. So it's the quality of the calories that we consume, and it's how we burn calories.
But we're learning that nitric oxide can turn genes on and turn genes off by histone modification, by affecting DNA methylation. So it's really controlling the epigenetic regulation of gene expression. So there's many things that affect that. But here's what we know in terms of fat deposition. So it's the quality of the calories that we consume, and it's how we burn calories.
And it's based on the TCA Krebs cycle, glycolysis, and things like that. How do we mobilize fuel? So there's not a lot of data really on the direct effects of nitric oxide on fat metabolism. We know that through turning yellow fat to brown fat or white fat to brown fat, it's the yellow visceral fat that's inflammatory.
And it's based on the TCA Krebs cycle, glycolysis, and things like that. How do we mobilize fuel? So there's not a lot of data really on the direct effects of nitric oxide on fat metabolism. We know that through turning yellow fat to brown fat or white fat to brown fat, it's the yellow visceral fat that's inflammatory.
And it's based on the TCA Krebs cycle, glycolysis, and things like that. How do we mobilize fuel? So there's not a lot of data really on the direct effects of nitric oxide on fat metabolism. We know that through turning yellow fat to brown fat or white fat to brown fat, it's the yellow visceral fat that's inflammatory.
The brown fat is more thermogenic because it contains more mitochondria, generating more energy. So we know that things like caloric restriction, intermittent fasting, the cold plunge, the contrast therapy, all that has been known to convert the yellow fat, the visceral fat into brown fat, more thermogenic, and you basically consume more fat or burn more fat.
The brown fat is more thermogenic because it contains more mitochondria, generating more energy. So we know that things like caloric restriction, intermittent fasting, the cold plunge, the contrast therapy, all that has been known to convert the yellow fat, the visceral fat into brown fat, more thermogenic, and you basically consume more fat or burn more fat.
The brown fat is more thermogenic because it contains more mitochondria, generating more energy. So we know that things like caloric restriction, intermittent fasting, the cold plunge, the contrast therapy, all that has been known to convert the yellow fat, the visceral fat into brown fat, more thermogenic, and you basically consume more fat or burn more fat.
I'm not a fan of it. I do it. It's not very fun. But no, usually when I'm at home every day, I start my day in a sauna, 170 degrees for 30 minutes. And then I do a three minute cold plunge at 37 degrees.
I'm not a fan of it. I do it. It's not very fun. But no, usually when I'm at home every day, I start my day in a sauna, 170 degrees for 30 minutes. And then I do a three minute cold plunge at 37 degrees.
I'm not a fan of it. I do it. It's not very fun. But no, usually when I'm at home every day, I start my day in a sauna, 170 degrees for 30 minutes. And then I do a three minute cold plunge at 37 degrees.
We know that nitric oxide can help the body restore and replace cells during sleep. And so aging is just wearing ourselves out and the inability to repair and replace dysfunctional cells or senescent cells. And we repair and replace when we sleep.
We know that nitric oxide can help the body restore and replace cells during sleep. And so aging is just wearing ourselves out and the inability to repair and replace dysfunctional cells or senescent cells. And we repair and replace when we sleep.
We know that nitric oxide can help the body restore and replace cells during sleep. And so aging is just wearing ourselves out and the inability to repair and replace dysfunctional cells or senescent cells. And we repair and replace when we sleep.
So if you're not getting good sleep or if you have obstructive sleep apnea or you're hypoxic when you sleep, you can't produce nitric oxide, you can't mobilize stem cells, and you don't repair and replace dysfunctional cells. So in terms of poor sleep on nitric oxide, there are many other things that are affecting nitric oxide production than poor sleep.
So if you're not getting good sleep or if you have obstructive sleep apnea or you're hypoxic when you sleep, you can't produce nitric oxide, you can't mobilize stem cells, and you don't repair and replace dysfunctional cells. So in terms of poor sleep on nitric oxide, there are many other things that are affecting nitric oxide production than poor sleep.
So if you're not getting good sleep or if you have obstructive sleep apnea or you're hypoxic when you sleep, you can't produce nitric oxide, you can't mobilize stem cells, and you don't repair and replace dysfunctional cells. So in terms of poor sleep on nitric oxide, there are many other things that are affecting nitric oxide production than poor sleep.
But poor sleep will certainly lead to a loss of nitric oxide production because if you're not fully oxygenated, if you're not mobilizing stem cells and repairing and replacing cells that can work properly, then you can't make nitric oxide. And you're chronically inflamed, you're stressed, and it's just a downward spiral.