Dr. Nathan Bryan

But poor sleep will certainly lead to a loss of nitric oxide production because if you're not fully oxygenated, if you're not mobilizing stem cells and repairing and replacing cells that can work properly, then you can't make nitric oxide. And you're chronically inflamed, you're stressed, and it's just a downward spiral.

But poor sleep will certainly lead to a loss of nitric oxide production because if you're not fully oxygenated, if you're not mobilizing stem cells and repairing and replacing cells that can work properly, then you can't make nitric oxide. And you're chronically inflamed, you're stressed, and it's just a downward spiral.

So today we know there's two ways that the human body makes it. One is through an enzyme called nitric oxide synthase. This enzyme is first found in our endothelial cells, the cells that line all blood vessels throughout the body. And so we call that ENOS. It's found in the neurons. We call it ENOS. It's found in our immune cells and activated macrophages. We call that inducible nitric oxide.

So today we know there's two ways that the human body makes it. One is through an enzyme called nitric oxide synthase. This enzyme is first found in our endothelial cells, the cells that line all blood vessels throughout the body. And so we call that ENOS. It's found in the neurons. We call it ENOS. It's found in our immune cells and activated macrophages. We call that inducible nitric oxide.

So today we know there's two ways that the human body makes it. One is through an enzyme called nitric oxide synthase. This enzyme is first found in our endothelial cells, the cells that line all blood vessels throughout the body. And so we call that ENOS. It's found in the neurons. We call it ENOS. It's found in our immune cells and activated macrophages. We call that inducible nitric oxide.

But really nitric oxide, the enzyme is found in most cells because every cell, part of that insulin signal transduction involves nitric oxide. So when that enzyme becomes dysfunctional, and it becomes what we call uncoupled, then it loses its ability to convert arginine, L-arginine, to nitric oxide. So that's number one. Number two is through the oral microbiome.

But really nitric oxide, the enzyme is found in most cells because every cell, part of that insulin signal transduction involves nitric oxide. So when that enzyme becomes dysfunctional, and it becomes what we call uncoupled, then it loses its ability to convert arginine, L-arginine, to nitric oxide. So that's number one. Number two is through the oral microbiome.

But really nitric oxide, the enzyme is found in most cells because every cell, part of that insulin signal transduction involves nitric oxide. So when that enzyme becomes dysfunctional, and it becomes what we call uncoupled, then it loses its ability to convert arginine, L-arginine, to nitric oxide. So that's number one. Number two is through the oral microbiome.

So the foods we eat, and I'm sure we'll address that, that are enriched in nitrate, the bacteria in and on the body convert that into nitrite and nitric oxide. So that obviously is dependent upon our diet. It's dependent upon the oral microbiome, and it's dependent upon stomach acid production. Any of those steps become compromised, and we lose the ability to make nitric oxide.

So the foods we eat, and I'm sure we'll address that, that are enriched in nitrate, the bacteria in and on the body convert that into nitrite and nitric oxide. So that obviously is dependent upon our diet. It's dependent upon the oral microbiome, and it's dependent upon stomach acid production. Any of those steps become compromised, and we lose the ability to make nitric oxide.

So the foods we eat, and I'm sure we'll address that, that are enriched in nitrate, the bacteria in and on the body convert that into nitrite and nitric oxide. So that obviously is dependent upon our diet. It's dependent upon the oral microbiome, and it's dependent upon stomach acid production. Any of those steps become compromised, and we lose the ability to make nitric oxide.

So one can compensate for the other. If we have poor endothelial function, if we eat a certain diet, we support the microbiome, and we have stomach acid, you can kind of compensate, if you will, for the lack of endothelial function.

So one can compensate for the other. If we have poor endothelial function, if we eat a certain diet, we support the microbiome, and we have stomach acid, you can kind of compensate, if you will, for the lack of endothelial function.

So one can compensate for the other. If we have poor endothelial function, if we eat a certain diet, we support the microbiome, and we have stomach acid, you can kind of compensate, if you will, for the lack of endothelial function.

But if you have endothelial dysfunction, a poor diet, and that's what most Americans are faced with, we see poor health, metabolic disease, hypertension, sexual dysfunction, cognition decline, and eventually Alzheimer's.

But if you have endothelial dysfunction, a poor diet, and that's what most Americans are faced with, we see poor health, metabolic disease, hypertension, sexual dysfunction, cognition decline, and eventually Alzheimer's.

But if you have endothelial dysfunction, a poor diet, and that's what most Americans are faced with, we see poor health, metabolic disease, hypertension, sexual dysfunction, cognition decline, and eventually Alzheimer's.

So just by way of clarification, we're ranking it based on overall health or overall nitric oxide production.

So just by way of clarification, we're ranking it based on overall health or overall nitric oxide production.

So just by way of clarification, we're ranking it based on overall health or overall nitric oxide production.