Dr. Nathan Bryan
speaker
1,178 appearances
5 recordings
3 series
first heard Feb 2025
last heard 3 Apr
Dr. Nathan Bryan’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 3 in all, peaking in Apr 2026 with 1.
Appearances
So the majority of my life, even as a kid, I was treating dad's wounds, the cubitus ulcers, pressure ulcers on his feet, on his butt. And he developed these non-healing wounds. He was diabetic, he was paraplegic, poor blood flow, hypertension, and he developed a non-healing wound, and no wound care doc that I took him to could heal this wound.
So I started making a topical nitric oxide, and I healed this wound within a period of four years of non-healing. I healed it within six months simply by giving nitric oxide and getting blood flow to that wound, killing the infection in the wound. And this was in a 60-something-year-old paraplegic, diabetic, sedentary old man.
You know, certainly it directed kind of my life because I witnessed the failure of the standard of care to treat dad with what I thought should be pretty simple. I mean, we have, again, the most advanced technology, medical technology, best medical schools in the world, and yet we can't treat a wound. We can't address the hypertension. We can't address the diabetes medically.
And so I just thought that there had to be a better way.
Yeah, but I see... You know, Dad, when I think I'm having a bad day, I just think, look, I'm not in a wheelchair. I got my health. So no matter how bad I think I got it, it could always be worse. So I just wake up every day with a grateful heart. And, you know, some days are good, some days are bad. But I always realize it could always be better, but it could be a hell of a lot worse.
So I don't complain.
I was in molecular and cellular physiology, got a PhD in molecular and cellular physiology. And that was, I was recruited by Fred Murad, one of the other guys who shared the Nobel Prize. to join the faculty at the University of Texas Health Science Center in Houston, which is the world's largest medical center, but it's part of the University of Texas system.
So I was recruited as a professor of molecular medicine, published probably, well, over 100 peer-reviewed scientific publications, I've edited several medical textbooks on the subject. I taught in medical school.
And then I resigned from academia, I guess, several years ago during COVID to focus on the next phase of my career is taking this 25 years of science and research and discovery and now bringing that to the fore for safe and effective product technology, drug therapies to eradicate a lot of these poorly managed chronic diseases that, you know, we're faced with today.
Well, it dilates the smooth muscle. It's not affecting the cells per se, but it's dilating the smooth muscle that surrounds the blood vessels, and that leads to relaxation and dilation.
That's right.
Well, yeah, there are a lot of things that occur with aging, right? We lose growth hormone with age. We lose many hormones. Nitric oxide is a hormone. We first discovered nitric oxide as a hormone back in 2007. But to understand aging, you have to understand what leads to aging. So aging, from my perspective, is the inability to repair and replace dysfunctional cells.
Every day we wear ourselves out, and if we can repair and replace dysfunctional cells, then we combat aging. or at least prolong the aging process. So what the science tells us in nitric oxide is this, that loss of nitric oxide production is the earliest event in the onset progression of age-related chronic disease.
So as that graph implies, it is part of the aging process, but it doesn't have to be. Because today we know we can shift that curve to the left or to the right. So we can accelerate it. And you see this today with 18-, 20-year-old kids that have high blood pressure. They have diabetes. They have erectile dysfunction. They have learning and cognitive impairment.
And those are all symptoms of nitric oxide deficiency. And to the contrary, we see 50-, 60-, 70-year-old patients that would fit on a 30- or 40-year-old scale on that graph. So this doesn't have to be the case. We know how to prevent this age-related decline in nitric oxide production. You know, I'm the best example.
I'm 51 years old, but I've got the vascular age of a 36-year-old because I employ these principles to prevent this age-related decline in nitric oxide production.
You look at the sort of vascular health of your... So there's several objective measures of biological age. Obviously, we can't affect our chronological age, right? But we can certainly affect our biological age. So what you can do, there's databases now that we call carotid intima media thickness.
So they take an ultrasound and look at your carotid arteries and they can look at what's called smooth muscle hyperplasia or the thickness of the intima and compare it to a database of age-matched kind of Really, you're comparing against your colleagues. So that's one way. Another way is looking at what's called flow-mediated dilatation or endothelial function.
And again, through database of hundreds of thousands or millions of patients, you can figure out where you fall on that spectrum on endothelial function. And then there's other markers looking at histone modification of the DNA, methylation profiles. There's a company or a technology called GlyconAge that looks at certain markers that can then define a biological age for each individual.
Yep. We've touched on them. So erectile dysfunction. 50% of the men over the age of 40 self-report erectile dysfunction. That's in the U.S. So think about that. 50% self-report. I think the numbers are higher because most 40-year-olds that I know are never going to admit that they have erectile dysfunction. So I think the numbers are even worse. So that's one. High blood pressure.
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