Dr. Nathan Bryan
speaker
1,178 appearances
5 recordings
3 series
first heard Feb 2025
last heard 3 Apr
Dr. Nathan Bryan’s voice in public audio — every appearance, attributed to the second.
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recordings per month · last 12 monthsRecordings per month over the last 12 months — 3 in all, peaking in Apr 2026 with 1.
Appearances
And so when you figure out that there's undue influence by these for-profit companies, because the number one rule of business, as you know as an entrepreneur and a business guy, is acquire a customer and keep that customer as long as you can. Call it lifetime value of that customer. And that's what medicine is. They get you, they acquire you as a customer. They put you on a drug.
That drug has side effects. They have to put you on another drug to mitigate the side effects of that drug. Now you've got side effects from that polypharmacy. They have to put you on another drug to mitigate those side effects. And now you look up and people who are 50 to 60 years old and older are on 10, 12, 18 different medications. That's the best financial model in the world.
So it's a great financial model, but it's at the expense of our health and the health of everybody living in the world. And in the U.S., you know, we have the sickest population in the world. Now, for the first time in the history of Western medicine, have discussions between physician and patient, how do we wean you off this drug?
That conversation has never had before because it's always, if this doesn't work, come back and I'll prescribe you more drugs. Let's do the opposite. You come back and let's understand the root cause of disease. Let's say, okay, well, if we are addressing this, you don't need this medication. And if you don't need this medication, you don't need this medication.
And now for the first time, you start weaning patients off of drugs. And what happens? You're now impeding upon the market share of these multi-billion dollar drug companies who make their living buying influence, regulating policy, influencing policy, And the FDA is a stepping stone to a board seat of Big Pharma. Every former FDA official in the U.S.
for the past 20 or 30 years goes on to become multimillion-dollar salaried employee from Big Pharma. It has to stop.
No, I mean, that's depressing. I mean, but those are the facts. And you have to understand, those are indisputable data, right? And so when people hear that, they go, but when you look at kind of the system, and I don't blame doctors because doctors are getting into this field. You know, I was on the admissions committee to UT Medical School for a number of years.
So we interviewed a lot of these young kids, figured out what their motivation was. Will they have a successful career in medicine? And almost everyone, I mean, there's always the exception, but everyone gets into medicine because they want to make a difference. They're driven by curiosity. And most of them want to leave a lasting legacy and help people. That's what drives entry into health care.
But when you look at the system in which they're trained in, it prevents them, it basically handcuffs them. Because when you figure out the pay, the economic model of medicine, once you make a diagnosis, now you've got a diagnosable disease to which you have a finite number of responses, right? If you make this diagnosis, that's called an ICD-10 code, which is reimbursable,
And that's how you get paid. So once you make a diagnosis, you only have a finite list of things you can do. You can't ask that question and go, well, what's really causing this and spend, you know, 90 minutes with that patient. Because most physicians have to see 60, 70, 80 patients a day to pay the bills, to cover their overhead. So it's a factory.
You come in, you look at it, you've got a transcriber, you make a diagnosis, okay, I'm going to prescribe this medication, come back in two weeks or six months and we'll see where you are. And then it's just, it's a churn, it's a meal. But as you meant, the data don't lie, right? Sickest population, highest infant mortality in the most industrialized nation in the world.
Well, again, longevity is this emerging field that's driven by how do we live longer? How do we increase our healthspan and longevity, right? Because I think we can all agree that nobody wants to live to be 100 years old if we spend the last 25 of that year as incapacitated, in a diaper, unable to get out of bed, right? That's not living.
So when I look at longevity, I look at kind of what are the hallmarks of longevity? What defines longevity, right? How do we live longer, healthier life free of disease? And really there's three objective measures. There is stem cells.
You know, this whole field of regenerative medicine is based on mobilizing our own stem cells or deploying stem cells throughout the body to repair and replace dysfunctional cells.
Well, we call them pluripotent stem cells. So mean that, and some of these are bone marrow derived. Some of these are what we call stromal vascular fraction that you get from the adipose tissue or the fat.
Pluripotent means that stem cell can go and become a neuron. That stem cell can go to the heart and become a functional myocyte. It can go and become a macrophage or an immune cell, white blood cell. So pluripotent means it can become many things, whatever it needs to be. In some cases, the amount of stem cells present in our bone marrow get smaller with age. The number of cells decrease with age.
But fortunately or unfortunately, the older we get, the more fat we deposit. And so we have a number of stem cells in our fat, so we increase the number of stem cells in our fat. So the problem with aging and longevity is when we lose the ability to mobilize our own stem cells, we can't repair and replace dysfunctional cells. So we have what we call zombie cells or senescent cells.
They're there, but they can't do their job. They're dysfunctional. And that's what leads to age. Number two, it's telomeres. And telomeres are the ends of the chromosomes of our DNA. And so they're the very end. So it's like the... the tips of the shoestrings, right? That prevent the shoestring from fraying.
And those are like the telomeres. So as long as you have a functional telomere and it prevents it from getting shorter, then shorter telomeres, shorter lifespan. Longer telomeres, longer lifespan. So when telomeres get shorter, it decreases our lifespan and longevity. And then the third one is mitochondrial function.
Every age-related chronic disease, you have a lower number of mitochondria per cell, and the mitochondria that are present aren't functional. So you get what's called an uncoupling of the electron transport chain inside the inner mitochondrial membrane, and you can no longer effectively produce cellular energy or ATP.
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