Dr. Nathan Bryan
speaker
1,178 appearances
5 recordings
3 series
first heard Feb 2025
last heard 3 Apr
Dr. Nathan Bryan’s voice in public audio — every appearance, attributed to the second.
Trend
recordings per month · last 12 monthsRecordings per month over the last 12 months — 3 in all, peaking in Apr 2026 with 1.
Appearances
So nitric oxide is the foundational longevity molecule because nitric oxide is the signal in the body that tells our stem cells to mobilize and differentiate. Without nitric oxide, you have less number of circulating stem cells. Nitric oxide activates the enzyme telomerase, which prevents telomere shortening. Without nitric oxide, you don't get activation of telomerase. Telomeres shorten.
And then nitric oxide is the signal in the cell that tells the cell, I need more mitochondria and I need these mitochondria to be more efficient, generate more cellular energy with less oxygen. So when you restore nitric oxide, you address all three aspects of longevity. And there's no other molecule in the body that does that.
You know, I would never replicate or try to do what he does. I don't think it's the proper approach. You know, and I don't mean to criticize people because this whole field of biohacking, you know, you get people who have no science background, no medical background, no biochemical background, and yet they're out there influencing people millions of people that follow him.
And many times they're giving really bad advice, not intentionally, it's because of ignorance. They just don't know. They don't know the science, they don't know the medicine behind it. So before you go and follow any influencer or biohacker, number one, look at their credentials.
And if they don't have any science background, if they're, you know, formal technologists or, you know, come from anything besides science and medicine, you really need to do a little bit of deep dive and make sure that what they're giving you is scientifically valid or recommending.
Yeah, I think as we advance the science and we do more to communicate the complex science into layman's terms where the non-scientists, non-medical professionals can understand it and appreciate it, I think more people are going to pick up to that.
But there's also some well-known biohackers with influences of millions of people that still say that nitric oxide is a toxin that inhibits mitochondrial respiration and it should be avoided.
Absolutely. We know water is essential, right? But we can drink too much water and kill ourselves. You see it on the news a couple of times a year called hypotonic lysis. So yeah, dose dictates poison.
And so what we have to do is make sure, maintain the integrity of the field to make sure that if there are nitric oxide products out there, that number one, you don't overdo it and lead to health issues or kill a consumer or kill a patient. Because that could kill the entire field. But we also understand that there's only two signs of toxicity for nitric oxide.
So it's really pretty straightforward. Number one, if you take too much nitric oxide, you're going to get an unsafe drop in blood pressure. Just think about this. If you take nitric oxide or you're enhancing nitric oxide production through whatever means, it's going to lead to systemic vasodilation.
Now you've got that same volume of blood pumping through much larger pipes, and you're going to have a drop in blood pressure. And if you lose perfusion pressure, you're not going to be able to perfuse the brain because you've got a pump against gravity, and you're going to get lightheaded and you'll pass out.
And if that's prolonged, it leads to ischemic end organ damage and organ failure, and it can be deadly. So that's number one. And then number two is a condition called methemoglobinemia. And that's a big word, meaning that it oxidizes the iron of hemoglobin and reduces your oxygen-carrying capacity. So you'll become cyanotic. You'll get blue around the lips.
Your extremities will turn white from lack of perfusion or lack of oxygen. But you never see that. I mean, you really never see clinical methemoglobinemia. Fortunately, your blood pressure will drop to an unsafe level long before you get any accumulation of methemoglobinemia.
Absolutely. So we understand at the DNA level, at the nuclear level, that nitric oxide is what's called a co-localizes with estrogen receptor to allow for the cell to turn on transcription and translation of the telomerase enzyme. So it's not only affecting the genetic transcription of that protein, but it's also regulating the function of the enzyme.
So without nitric oxide, you have less telomere telomerase enzyme, and that telomerase enzyme isn't functional.
So what happens with each cellular division, those telomeres can get shorter.
Right? But as long as that telomerase enzyme is active, it prevents the shortening of the very ends of the chromosome.
Yeah, and different cell types have different replication rates, right? So the epithelium of the gut is highly regenerative, right? It's replicatable. We're replacing these cells all the time because it's the outside environment that you're having to continue to replace those cells. Neurons, to the exact opposite, aren't regenerative by nature. So we don't typically make them. I mean, we can.
It was once thought that you can't regenerate neurons, but today we know we can't. But yeah, so it affects different organ systems differently. But the data are clear, shorter telomeres, shorter lifespan.
Yeah.
Showing 801–820 of 1,178 · page 41 of 59
← Previous
Next →