Dr. Nolan Williams

We restore the governance of the left dorsolateral over the cingulate area, and that is correlated with treatment improvement.

So the degree in which you can

re-time, re-regulate in time the left dorsolateral over the cingulate, the more of an antidepressant effect you have.

TMS is almost like exercise for the brain, right?

You're kind of exercising this region over and over again with a physiologically relevant

signal and kind of turning that system on.

And what's interesting for this show is we had a couple of folks, probably five or six folks that have actually told me this, where if they remit early enough in the week, we have this very dense stimulation approach where we can stimulate people really rapidly over a five-day block.

By Wednesday, they're like totally zeroed out on the depression scales, you know, even

better than most people walking around, like really no anxiety, no depression or anything.

By Thursday, the first guy that told me this, he came in and he said, you know, I was driving back to my hotel and I decided to go to the beach and I just sat there and I was totally present in the present moment for an hour.

And he's like, I read about this in my mindfulness books, but I experienced it.

last night and i've never experienced anything like this before and i was like hmm that's interesting but kind of wasn't sure and then and then i didn't tell any you know obviously any more patients about that and then about five over the last couple of years when they get they were met early in the week by the end of the week they're like going to the beach and they're like totally having a what people describe as a pretty mindful present moment sort of experience

Which is really interesting, you know, what that is.

I mean, I don't have full-on scientific data to tell you, but it's just, it's an interesting anecdote, right?

That folks, when you push them through this point of feeling kind of clinically well, that some people end up reporting this additional set of features.

SSRIs clearly work.

You know, many, many meta-analyses kind of proving that out, right?

that in a subpopulation of individuals, they achieve great benefit for depression, for obsessive compulsive disorder, for generalized anxiety disorder, panic, you know, all these things.

You can see an improvement in those symptoms with what we call SSRIs or selective serotonin reuptake inhibitors.

The issue is that they don't work immediately, right?