Dr. Ori Stollar

SSRIs don't just increase the serotonin in the brain, because then you don't need SSRIs. You need to take serotonin, and maybe that will kind of go into your brain. They actually change the receptors in the brain. And they change specific receptors in the brain, which will have the behavioral effect. And, and let me Can I stop you?

SSRIs don't just increase the serotonin in the brain, because then you don't need SSRIs. You need to take serotonin, and maybe that will kind of go into your brain. They actually change the receptors in the brain. And they change specific receptors in the brain, which will have the behavioral effect. And, and let me Can I stop you?

four to eight weeks. That's actually very, very interesting. And again, if you really want to go into the mechanism of it, I mean, maybe layman because we have a different audience like I would love to hear if someone wants to dig a little bit deeper, I would go with the book by stall the psycho pharmacology book. That's a human psycho pharmacology book by style.

four to eight weeks. That's actually very, very interesting. And again, if you really want to go into the mechanism of it, I mean, maybe layman because we have a different audience like I would love to hear if someone wants to dig a little bit deeper, I would go with the book by stall the psycho pharmacology book. That's a human psycho pharmacology book by style.

Basically, it's because we're not just... I mean, yes, we're increasing the serotonin at the beginning, but the actual effect is by affecting different 5-HT and serotonin receptors. And some of them are inhibitory receptors, and some of them need to be basically produced. So at the beginning, we actually have very high levels of serotonin, which might...

Basically, it's because we're not just... I mean, yes, we're increasing the serotonin at the beginning, but the actual effect is by affecting different 5-HT and serotonin receptors. And some of them are inhibitory receptors, and some of them need to be basically produced. So at the beginning, we actually have very high levels of serotonin, which might...

attached to the inhibitory receptors, which is more associated with, and again, I'm trying not to overcomplicate things because it's complicated, but basically because they attach to specific receptors in the synapses, they cause those side effects. And by the way, there are serotonin receptors in other parts in the body, not just the brain.

attached to the inhibitory receptors, which is more associated with, and again, I'm trying not to overcomplicate things because it's complicated, but basically because they attach to specific receptors in the synapses, they cause those side effects. And by the way, there are serotonin receptors in other parts in the body, not just the brain.

So again, they might have other side effects because of that effect. And the changes in the amount of receptors and the sensitivity of those receptors, that changes take longer. So that's why at the beginning when we actually have very high serotonin because of the medication and all of that, we see side effects that are more common in the first two weeks.

So again, they might have other side effects because of that effect. And the changes in the amount of receptors and the sensitivity of those receptors, that changes take longer. So that's why at the beginning when we actually have very high serotonin because of the medication and all of that, we see side effects that are more common in the first two weeks.

then usually we'll see that the side effects are improving, but not necessarily see the actual clinical effect. The clinical effect itself takes between four to eight weeks, like you mentioned. And that's again, that's because of the actual changes in the proteins that are produced and create those receptors in the synapses and that takes a few weeks, and only then we'll see.

then usually we'll see that the side effects are improving, but not necessarily see the actual clinical effect. The clinical effect itself takes between four to eight weeks, like you mentioned. And that's again, that's because of the actual changes in the proteins that are produced and create those receptors in the synapses and that takes a few weeks, and only then we'll see.

But going back to your original question about how we actually know if it's working or not, then a side of how we if it's working or not, but when we say when we say that, the question is, how do we measure that happiness increased?

But going back to your original question about how we actually know if it's working or not, then a side of how we if it's working or not, but when we say when we say that, the question is, how do we measure that happiness increased?

No, no, no, definitely not. Definitely not. So it really depends on the situation. If we're dealing with a dog, that's, you know, kind of like how you would imagine a person with ADHD. I'm not talking about like playful behavior. I'm talking about the dog that just can't relax. And you know, some some will also say that we don't need to treat ADHD as much.

No, no, no, definitely not. Definitely not. So it really depends on the situation. If we're dealing with a dog, that's, you know, kind of like how you would imagine a person with ADHD. I'm not talking about like playful behavior. I'm talking about the dog that just can't relax. And you know, some some will also say that we don't need to treat ADHD as much.

And it's also there's a rise in how many people are being treated for it. But let's say that if we have a dog that, you know, is, and it is sometimes anxiety can go both ways, it can cause a dog to be hyper all the time, for sure, all over the place. And it can cause the dog to look like, you know, we would use the word depressed, even though we don't really know if it's actually depression. But

And it's also there's a rise in how many people are being treated for it. But let's say that if we have a dog that, you know, is, and it is sometimes anxiety can go both ways, it can cause a dog to be hyper all the time, for sure, all over the place. And it can cause the dog to look like, you know, we would use the word depressed, even though we don't really know if it's actually depression. But

it might go to both ways. So yes, sometimes it's a lot easier if you have a depressed dog or those anxious dogs that, you know, are kind of like in a shell and all of a sudden they're coming out of their shell. It's a lot easier to say, oh, yes, it's working. harder sometimes to say, when you have a dog that's all over the place, but also aggressive.

it might go to both ways. So yes, sometimes it's a lot easier if you have a depressed dog or those anxious dogs that, you know, are kind of like in a shell and all of a sudden they're coming out of their shell. It's a lot easier to say, oh, yes, it's working. harder sometimes to say, when you have a dog that's all over the place, but also aggressive.