Dr. Paul Offit
๐ค SpeakerAppearances Over Time
Podcast Appearances
That's not enough time for those memory cells to become activated and make antibodies, for example, to prevent mild disease. So you're always going to get mild disease again and again. I mean, we'll be living with COVID for the rest of your life and my life and my children's life. and my two new grandchildren's lives. I mean, so this is going to be around for a while.
And I just think we have to get people to understand that you may still get mild disease again and again. The goal is to keep you out of the hospital. That's the goal.
And I just think we have to get people to understand that you may still get mild disease again and again. The goal is to keep you out of the hospital. That's the goal.
And I just think we have to get people to understand that you may still get mild disease again and again. The goal is to keep you out of the hospital. That's the goal.
Yeah, so if you're... As a general rule, memory cells are lifelong. So if there was a member study done with an isolated island nation that had a measles epidemic. Okay, then everybody got it and it faded away. And then that was it. It wasn't circulating anymore in the community. And then like 40 years passed and some sailors from another country came and reintroduced it.
Yeah, so if you're... As a general rule, memory cells are lifelong. So if there was a member study done with an isolated island nation that had a measles epidemic. Okay, then everybody got it and it faded away. And then that was it. It wasn't circulating anymore in the community. And then like 40 years passed and some sailors from another country came and reintroduced it.
Yeah, so if you're... As a general rule, memory cells are lifelong. So if there was a member study done with an isolated island nation that had a measles epidemic. Okay, then everybody got it and it faded away. And then that was it. It wasn't circulating anymore in the community. And then like 40 years passed and some sailors from another country came and reintroduced it.
And it would again cause disease in younger people who hadn't been exposed to it. But all those older people, 40, 50, 60-year-old people never got it because they had immunological memory, which tells you that it is very long-lived. Memory cells are long-lived. They remember for a long time. So for long incubation period diseases, you're protected for the rest of your life.
And it would again cause disease in younger people who hadn't been exposed to it. But all those older people, 40, 50, 60-year-old people never got it because they had immunological memory, which tells you that it is very long-lived. Memory cells are long-lived. They remember for a long time. So for long incubation period diseases, you're protected for the rest of your life.
And it would again cause disease in younger people who hadn't been exposed to it. But all those older people, 40, 50, 60-year-old people never got it because they had immunological memory, which tells you that it is very long-lived. Memory cells are long-lived. They remember for a long time. So for long incubation period diseases, you're protected for the rest of your life.
I mean, I'm a child of the 50s. I had measles, mumps, German measles, chickenpox, because I was born and was a child before any of those vaccines were introduced. I am protected for the rest of my life against those viruses.
I mean, I'm a child of the 50s. I had measles, mumps, German measles, chickenpox, because I was born and was a child before any of those vaccines were introduced. I am protected for the rest of my life against those viruses.
I mean, I'm a child of the 50s. I had measles, mumps, German measles, chickenpox, because I was born and was a child before any of those vaccines were introduced. I am protected for the rest of my life against those viruses.
You're testing for antibody, which will fade. So what you really want to be testing for is the frequency of memory B cells or the frequency of memory T cells, which are research tools. That's not the kind of thing that's easily commercially available. But I think it's possible that if you test me, I'm not going to have circulating antibodies against measles.
You're testing for antibody, which will fade. So what you really want to be testing for is the frequency of memory B cells or the frequency of memory T cells, which are research tools. That's not the kind of thing that's easily commercially available. But I think it's possible that if you test me, I'm not going to have circulating antibodies against measles.
You're testing for antibody, which will fade. So what you really want to be testing for is the frequency of memory B cells or the frequency of memory T cells, which are research tools. That's not the kind of thing that's easily commercially available. But I think it's possible that if you test me, I'm not going to have circulating antibodies against measles.
But if you test me, I think I will, even at this age, still have memory T cells and B cells, which will protect me against those diseases.
But if you test me, I think I will, even at this age, still have memory T cells and B cells, which will protect me against those diseases.
But if you test me, I think I will, even at this age, still have memory T cells and B cells, which will protect me against those diseases.
Many won't, though. Oh, really?