Dr. Peter Attia

Now, pregabalin can also lead to weight gain. Doesn't it also increase appetite? Both.

Now, pregabalin can also lead to weight gain. Doesn't it also increase appetite? Both.

And they also both enhance sleep, especially pregabalin. And so there's a little bit of an added benefit to patients who were using these to also put the pain out at night when it can be most noticeable.

And they also both enhance sleep, especially pregabalin. And so there's a little bit of an added benefit to patients who were using these to also put the pain out at night when it can be most noticeable.

There was actually a study, I don't know if I'll ever be able to find it, it was sent to me that actually suggested pregabalin didn't just make you drowsy, which was obvious, but also promoted appropriate sleep architecture.

There was actually a study, I don't know if I'll ever be able to find it, it was sent to me that actually suggested pregabalin didn't just make you drowsy, which was obvious, but also promoted appropriate sleep architecture.

I could be totally wrong on that, but it could be your experience.

I could be totally wrong on that, but it could be your experience.

And again, you're using these for the most recalcitrant neuropathic pain typically?

And again, you're using these for the most recalcitrant neuropathic pain typically?

We didn't even do this, I'm sorry. We didn't define chronic pain, but how would you put a definition on that?

We didn't even do this, I'm sorry. We didn't define chronic pain, but how would you put a definition on that?

Antidepressants and their role in pain management?

Antidepressants and their role in pain management?

Sorry, how much lidocaine? I hope it wasn't toxic. I'll come back to the story. It's pretty funny. I'm looking forward to it. Which TCAs are the popular ones? Everybody... I think there's about nine. What are your top two or three?

Sorry, how much lidocaine? I hope it wasn't toxic. I'll come back to the story. It's pretty funny. I'm looking forward to it. Which TCAs are the popular ones? Everybody... I think there's about nine. What are your top two or three?

Oh, amitriptyline. Yep, yep.

Oh, amitriptyline. Yep, yep.

Is it offset by GLP-1 agonists in the modern era?

Is it offset by GLP-1 agonists in the modern era?