Dr. Peter Attia

Awesome. Okay, I'm going to repeat that question. So there were two questions there. The first was an update on clotho, and I'll explain what that is for everybody else. And then the second was on the gram of protein per pound of body weight. Is it ideal body weight if a person is overweight? I'll start with the second question. The short answer is... It depends on how overweight.

Awesome. Okay, I'm going to repeat that question. So there were two questions there. The first was an update on clotho, and I'll explain what that is for everybody else. And then the second was on the gram of protein per pound of body weight. Is it ideal body weight if a person is overweight? I'll start with the second question. The short answer is... It depends on how overweight.

So if a person came to me and said, look, I weigh 260 pounds. I probably should weigh 200 pounds. I would tell them if I agreed with that assessment, I'd say being closer to the 200 is probably fine. You don't need to be at the 260. Okay, this gentleman was asking about a podcast I did. So I don't know how many months ago it was, six, nine months ago. I had an amazing scientist on my podcast.

So if a person came to me and said, look, I weigh 260 pounds. I probably should weigh 200 pounds. I would tell them if I agreed with that assessment, I'd say being closer to the 200 is probably fine. You don't need to be at the 260. Okay, this gentleman was asking about a podcast I did. So I don't know how many months ago it was, six, nine months ago. I had an amazing scientist on my podcast.

Her name was Dina DuBall. She's a neurologist at University of California, San Francisco, and she studies a protein called clotho. This is a protein that is made by the body. It is made in response to exercise, but it also is just made endogenously and declines with age for reasons we don't understand. So children make six times more of this than adults.

Her name was Dina DuBall. She's a neurologist at University of California, San Francisco, and she studies a protein called clotho. This is a protein that is made by the body. It is made in response to exercise, but it also is just made endogenously and declines with age for reasons we don't understand. So children make six times more of this than adults.

But of course, any one of us can transiently increase it by exercising. What's special about this protein is it seems to be one of the most important proteins that protects the brain. And so in both mice and monkeys, when you inject this protein, if these are animals that have signs of dementia or cognitive decline, it reverses.

But of course, any one of us can transiently increase it by exercising. What's special about this protein is it seems to be one of the most important proteins that protects the brain. And so in both mice and monkeys, when you inject this protein, if these are animals that have signs of dementia or cognitive decline, it reverses.

If these are normal animals, they seem to get superpowers, like supercognitive powers. So that protein is going to be tested over the next three years in humans. And if the results of that look promising, then a larger clinical trial will take place.

If these are normal animals, they seem to get superpowers, like supercognitive powers. So that protein is going to be tested over the next three years in humans. And if the results of that look promising, then a larger clinical trial will take place.

So I would say the best case scenario here would be that in seven to 10 years, this could be an actual drug that humans take either to prevent cognitive decline or to treat it.

So I would say the best case scenario here would be that in seven to 10 years, this could be an actual drug that humans take either to prevent cognitive decline or to treat it.

So what is the best type of protein supplement you recommend to get to your grams?

So what is the best type of protein supplement you recommend to get to your grams?

So I always ask people, if possible, and it's not always possible, whatever you can get from food is great. But I understand that for many people, and again, especially for women, it's really hard to just mash through that much protein. So we turn to supplements. Now, when it comes to foods, the three that stand out the most are dairy products,

So I always ask people, if possible, and it's not always possible, whatever you can get from food is great. But I understand that for many people, and again, especially for women, it's really hard to just mash through that much protein. So we turn to supplements. Now, when it comes to foods, the three that stand out the most are dairy products,

beef and eggs, because there's a quantitative way that you measure both the type of amino acid and what's called bioavailability of the amino acid. So how complete are the sources of amino acids and how readily can the body access them? So again, if you're thinking about eating, beef, eggs, and dairy are the big ones. You can get lots of amino acids and lots of other proteins.

beef and eggs, because there's a quantitative way that you measure both the type of amino acid and what's called bioavailability of the amino acid. So how complete are the sources of amino acids and how readily can the body access them? So again, if you're thinking about eating, beef, eggs, and dairy are the big ones. You can get lots of amino acids and lots of other proteins.

I'm not saying don't eat chicken or fish or vegetable proteins, but those are big ones. Therefore, when you're supplementing whey protein, which comes from dairy, tends to be the winner. Now, casein is also great because it's also from dairy. So whey or casein probably stand out a little bit above, but so does egg protein supplement.

I'm not saying don't eat chicken or fish or vegetable proteins, but those are big ones. Therefore, when you're supplementing whey protein, which comes from dairy, tends to be the winner. Now, casein is also great because it's also from dairy. So whey or casein probably stand out a little bit above, but so does egg protein supplement.