Dr. Peter Attia
speaker
5,258 appearances
36 recordings
6 series
first heard Jan 2024
last heard Jun 2025
Dr. Peter Attia’s voice in public audio — every appearance, attributed to the second.
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Appearances
And frankly, a lot of people just, I mean, I used to even get nauseous on Flexeril. But something about Baclofen, I don't even know it's in me at 20 milligrams twice a day, but it actually takes the edge off. And where I typically find this beneficial is is if I slept wrong and I get a kink in my trap, or I've been on a super long drive and my QLs sort of flare a little bit.
And I know that if I had all the time in the world, I could go and stretch my way out of that. But sometimes I just don't have that time and I need to kind of get right back to doing something awful like sitting. And just two or three days of 20 milligrams of baclofen BID with a little NSAID and like, I'm as good as new and I save myself the real flare up.
What are your experience with muscle relaxants?
So how many days are you comfortable with a person?
What doses typically, or is it just individual?
And what dose are you comfortable up to 20 milligrams three times a day?
Okay. You alluded to Neurontin earlier, and you alluded to the fact that it played a role in my recovery because once we got the big stuff out of the way, I still had a couple of years of peripheral nerve injury. And the only way to put the fire out in my foot was Neurontin. And unfortunately, initially it required four grams a day. I was taking a gram four times a day or something like that.
And the good news is it worked. The bad news is you're pretty much always tired. So I was very happy over time to get that dose down. And I think within 18 months, I was completely off the Neurontin and lo and behold, never experienced. Although interestingly, maybe once every year, I get like an enormous surge of fire into that same foot.
literally one shot of flame that lasts seconds and it's gone, but essentially never again. Is Neurontin still a very powerful tool in the use of neuropathic pain? You alluded to other drugs like antidepressants as well, in addition to a rather impotent anti-seizure med, but what else do you have at your disposal for this type of pain?
You could fall asleep driving.
Now, pregabalin can also lead to weight gain. Doesn't it also increase appetite? Both.
And they also both enhance sleep, especially pregabalin. And so there's a little bit of an added benefit to patients who were using these to also put the pain out at night when it can be most noticeable.
There was actually a study, I don't know if I'll ever be able to find it, it was sent to me that actually suggested pregabalin didn't just make you drowsy, which was obvious, but also promoted appropriate sleep architecture.
I could be totally wrong on that, but it could be your experience.
And again, you're using these for the most recalcitrant neuropathic pain typically?
We didn't even do this, I'm sorry. We didn't define chronic pain, but how would you put a definition on that?
Antidepressants and their role in pain management?
Sorry, how much lidocaine? I hope it wasn't toxic. I'll come back to the story. It's pretty funny. I'm looking forward to it. Which TCAs are the popular ones? Everybody... I think there's about nine. What are your top two or three?
Oh, amitriptyline. Yep, yep.
Is it offset by GLP-1 agonists in the modern era?
Showing 1081–1100 of 5,258 · page 55 of 263
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