Dr. Peter Attia
speaker
5,258 appearances
36 recordings
6 series
first heard Jan 2024
last heard Jun 2025
Dr. Peter Attia’s voice in public audio — every appearance, attributed to the second.
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Appearances
Put a black box label on it and we should all still have access to Merck's.
The baby got thrown out with the bathwater on that one.
Why do you think there hasn't been any drug that's come close to that? Like Celebrex is a joke. Like none of the drugs that are in the...
Do you have a version on dose? I mean, do you say 800 milligrams of ibuprofen TID three times a day, 2400 milligrams would be, you would tolerate that for how many days if a person needed it? Week to two weeks on that.
You're eating. Yeah.
Yeah, it is interesting that we can buy acetaminophen and ibuprofen over the counter, and yet they can cause a ton of damage if not taken correctly.
Liver failure. Let's talk about acetaminophen for a while. When I last tried to understand it, there was no clue as to how it worked. To this day, do we understand how it works?
But there's a nice synergy with acetaminophen and ibuprofen because different mechanism of action, different organ systems are impacted. So you can take less of each when you combine them. What's your take on that?
Yeah. My go-to stack, if I am actually in pain, a year ago, I had to get a crown put on a tooth that had an old filling that broke. And it's the funniest thing because of how remarkable the teeth are at sensation, but the crown was a little too high. Okay, so what's the impact of that? That meant every time I took a bite, that one tooth was bearing the brunt of it.
It was the last tooth I had right in front of my wisdom tooth. And I'm talking to my dentist and he's like, yeah, Peter, it's just too high. Just come in and let me shave a little bit of it off. Well, I didn't have the time to go in. So for two months, I did not go in to get this thing shaved off. The pain was, this is how stupid I am.
Like I couldn't spare the two hours to go to the dentist and he was willing to see me nights and weekends. This is the most accommodating dentist in the world. Everybody should have that kind of dentist. Tony Pacheco. I can't say enough about him. And yet I couldn't make the time. So for two months, the pain got so bad that eventually couldn't chew on that side at all.
So my point is I had to be taking something to get through the day. And the stack that worked was 400 of Advil, 500 of Tylenol, three times a day. Okay. Took care of me.
I don't know, but the reason I prefer it is that I can line up the dosing with the acetaminophen because I believe naproxen you only take once a day, right? Twice a day. Twice a day. Okay. You're right.
I wanted something where I could do it TID instead of BID.
Okay.
Are there types of pains people should be thinking of where these things work especially well and other areas where, yeah, that's just not going to have much efficacy?
So you're saying maybe we should be empirical. In other words, try the naproxen, try the ibuprofen, figure out which one works. Obviously, don't take them together.
Do you have a concern with people taking acetaminophen and consuming alcohol? Do you tell people to refrain from alcohol when they're taking Tylenol?
I typically, when I'm taking acetaminophen, I don't drink much anyway. I'm probably going to have four drinks in a week. So meaning four days a week, I will have a drink or three days a week. But if I am taking Tylenol, I'm just going to refrain. Again, I don't have any evidence to suggest that that's necessary. Probably the safest. It's the precautionary principle at its finest.
Okay, I want to talk about muscle relaxants. So the other thing that has been a real favorite tool of mine is baclofen. Now, it's not a particularly potent muscle relaxant, but it seems to, for me and for the patients of mine in whom it works, offer something really potent like Valium. Doesn't bring all the baggage of a benzo. or even a Flexeril where you can kind of get the drowsiness.
Showing 1061–1080 of 5,258 · page 54 of 263
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