Dr. Rhonda Patrick

And what what is this state of like pre pre diabetes?

And why is it something that is not caught sooner?

Oh, I definitely want to get into that.

Well, just sort of as a follow-up question, in this world we live in now where continuous glucose monitors are so becoming very popular, many people have them, without a prescription you can get them.

Yep.

Is there any signs or tests using those that people can do to kind of look for this potential problem with having perhaps high insulin?

In fact, they're not measuring insulin, but glucose.

So many researchers, including yourself, do view insulin resistance as a sort of root of causing many different types of chronic diseases, age-related diseases, obviously type 2 diabetes, obesity is in there, cardiovascular disease.

Alzheimer's, fatty liver disease, infertility.

So why is that?

Yeah.

Something that people think is the root cause of so many chronic diseases.

And again, you're talking about insulin resistance being common and certainly like this pre-pre-diabetic state being pretty common.

What do you think the reason for that is?

So some researchers think that the high insulin is more of a response to ectopic fat accumulation, obesity sort of being the underlying cause of the high insulin.

So how do you kind of differentiate between this cause and effect?

What role does ectopic fat accumulation have in insulin resistance causing high insulin?

Yeah, well, this is, we've got a lot to dive into here.

I mean, it's funny, I remember one of my first projects as a budding young scientist was to look at insulin resistance, like free fatty acids, and can you make like a little nematode worm insulin resistant?

And, you know, it, from my understanding, had to do with the adipocyte cell and this sort of spillover