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Dr. Rhonda Patrick

๐Ÿ‘ค Speaker
6660 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Essentials: Micronutrients for Health & Longevity | Dr. Rhonda Patrick

And they do it in a way that is not only beneficial to help you deal with that little stressor, exercise or heat, it stays active and it helps you deal with the stress of stress.

Huberman Lab
Essentials: Micronutrients for Health & Longevity | Dr. Rhonda Patrick

normal metabolism, normal immune function happening, just life, aging, right?

Huberman Lab
Essentials: Micronutrients for Health & Longevity | Dr. Rhonda Patrick

So this concept is referred to as hormesis, right?

Huberman Lab
Essentials: Micronutrients for Health & Longevity | Dr. Rhonda Patrick

This has a very profound antioxidant, anti-inflammatory response or, you know, or whatever the response is.

Huberman Lab
Essentials: Micronutrients for Health & Longevity | Dr. Rhonda Patrick

It could be the production of more stem cells or something like autophagy.

Huberman Lab
Essentials: Micronutrients for Health & Longevity | Dr. Rhonda Patrick

These stress response pathways are activated like by a variety of stressors.

Huberman Lab
Essentials: Micronutrients for Health & Longevity | Dr. Rhonda Patrick

So for example, one pathway is called heat shock proteins and

Huberman Lab
Essentials: Micronutrients for Health & Longevity | Dr. Rhonda Patrick

And as their name would apply, one would go, oh, they're activated by heat.

Huberman Lab
Essentials: Micronutrients for Health & Longevity | Dr. Rhonda Patrick

Well, correct.

Huberman Lab
Essentials: Micronutrients for Health & Longevity | Dr. Rhonda Patrick

They are activated very robustly by heat.

Huberman Lab
Essentials: Micronutrients for Health & Longevity | Dr. Rhonda Patrick

But you can eat a plant like broccoli sprouts, which is high in something called sulforaphane.

Huberman Lab
Essentials: Micronutrients for Health & Longevity | Dr. Rhonda Patrick

And it activates heat shock proteins, among other things.

Huberman Lab
Essentials: Micronutrients for Health & Longevity | Dr. Rhonda Patrick

It also activates a very powerful detoxification pathway called NRF2, which helps you detoxify things like carcinogens that you're exposed to.

Huberman Lab
Essentials: Micronutrients for Health & Longevity | Dr. Rhonda Patrick

Cold also activates heat shock proteins.

Huberman Lab
Essentials: Micronutrients for Health & Longevity | Dr. Rhonda Patrick

Now, you're going to more robustly activate heat shock proteins from heat rather

Huberman Lab
Essentials: Micronutrients for Health & Longevity | Dr. Rhonda Patrick

versus cold, but there is some overlap.

Huberman Lab
Essentials: Micronutrients for Health & Longevity | Dr. Rhonda Patrick

These generalizations are kind of, they're just not useful.

Huberman Lab
Essentials: Micronutrients for Health & Longevity | Dr. Rhonda Patrick

And I think that a lot of people online in the blogosphere

Huberman Lab
Essentials: Micronutrients for Health & Longevity | Dr. Rhonda Patrick

they gravitate towards them because it's just easier and it's a lot more sensational.

Huberman Lab
Essentials: Micronutrients for Health & Longevity | Dr. Rhonda Patrick

But I do think with respect to plants, there's just evidence that sulforaphane is a very powerful activator of the NRF2 pathway.